| SUMO化修饰:一种多功能的蛋白质翻译后修饰方式 |
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| 引用本文： | 刘世荣,何维.SUMO化修饰:一种多功能的蛋白质翻译后修饰方式[J].医学分子生物学杂志,2006,3(3):212-215. |
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| 作者姓名： | 刘世荣 何维 |
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| 作者单位： | 中国医学科学院中国协和医科大学基础医学院免疫学系,北京市,100005 |
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| 摘 要： | SUMO分子是一种结构上与泛素相似的分子,它参与蛋白质翻译后修饰。SUMO化循环与泛素化循环过程相似,但SUMO化修饰具有与泛素化修饰截然不同的功能。泛素化修饰的靶分子主要被蛋白酶体降解,而SUMO化修饰则介导靶分子定位和功能调节。新近发现SUMO化修饰参与调控线粒体分裂、DNA损伤修复及调节基因组稳定性、调控离子通道及生物节律。此外,SUMO化修饰功能的紊乱会导致某些疾病的发生。
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| 关 键 词： | 小泛素相关修饰物 翻译后修饰 |
| 修稿时间： | 2006年1月9日 |
Sumoylation-A Multifunctional Post-translational Protein Modification |
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| LIU Shirong,HE Wei.Sumoylation-A Multifunctional Post-translational Protein Modification[J].Journal of Medical Molecular Biology,2006,3(3):212-215. |
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| Authors: | LIU Shirong HE Wei |
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| Abstract: | The small ubiquitin-related modifier(SUMO)family proteins are structurally and mechanistically related to ubiquitin.Other than degradation of ubiquitinized target proteins by the 26S proteasome,sumoylation appears to play important roles in protein targeting and functional regulation of substrate proteins.Recent research revealed that sumoylation is involved in mitochondrial fission,DNA repair,the ion channel control and circadian clock.Many diseases or disorders are shown to be related to sumoylation/ desumoylation cycle. |
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| Keywords: | small ubiquitin-related modifier proteins protein processing post-translational |
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