冠心病患者高密度脂蛋白胆固醇与冠脉病变的相关性研究

目的探讨血浆高密度脂蛋白胆固醇(HDL-C)水平与冠脉病变的关系。方法选取153例行冠脉造影确诊的冠心病患者,并对冠脉病变程度进行分型,观察其与各项冠心病危险因素相关指标的关系。结果冠心病患者HDL-C比对照组明显降低,而总胆固醇(TC)、体重指数(BMI)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)比对照组明显增加,急性冠脉综合征组(ACS)患者比稳定型心绞痛组(ACS)HDL-C明显降低,TC明显增加P<0.001。HDL-C与冠脉病变类型、病变支数成负相关,TC与之成正相关。结论HDL-C与冠脉病变程度具有负相关关系。血HDL-C水平有可能成为一项有价值的、能预测冠心病事件的检查方法。

Relationship between HDL-C and coronary artery lesions in patients with coronary heart disease

Objective To investigate the relationship between HDL-C and coronary artery lesions in patients with coronary heart disease(CHD). Methods 153 patients with CHD who undergone coronary angiography were admitted. The severity of coronary artery lesions was analyzed and classified and the levels of plasma lipids were tested. Results CHD patients had lower HDL-C and higher TC, BMI,TG , LDL-C than controls. Patients with acute coronary syndrome(ACS) had lower HDL-C and higher TC than stable angina pectoris(SAP), P<0.001. Plasma HDL-C correlated negatively and TC correlated positively with the numbers and classification of coronary artery lesions. Conclusion Higher HDL-C concentration has protective effect on coronary artery ,especially for high risk population. It is valuable method to predict the incidents of coronary artery disease.