| 高效液相色谱法测定复方芩兰口服液中连翘苷含量 |
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| 引用本文： | 孔涛,张月芹. 高效液相色谱法测定复方芩兰口服液中连翘苷含量[J]. 中国药业, 2012, 0(22): 52-53 |
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| 作者姓名： | 孔涛 张月芹 |
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| 作者单位： | 山东省济宁市妇幼保健院;山东省鱼台县妇幼保健院 |
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| 摘 要： | 目的建立测定复方芩兰口服液中连翘苷含量的高效液相色谱法。方法采用C18色谱柱（250 mm×4.6 mm,5μm）,流动相为乙腈-水（25∶75）,流速为1.0 mL/min,检测波长为278 nm。结果连翘苷进样量在1.22～12.2μg范围内与峰面积呈良好线性关系,r=0.999 5,平均回收率为98.66%,RSD=0.72%（n=6）。结论建立的方法简便、准确、重复性好,可用于该制剂的质量控制。
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| 关 键 词： | 高效液相色谱法 复方芩兰口服液 连翘苷 含量测定 |
Determination of Forsythin in Compound Qinlan Oral Liquid by HPLC |
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| Kong Tao,Zhang Yueqin. Determination of Forsythin in Compound Qinlan Oral Liquid by HPLC[J]. China Pharmaceuticals, 2012, 0(22): 52-53 |
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| Authors: | Kong Tao Zhang Yueqin |
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| Affiliation: | 1.Jining Municipal Maternal and Child Health Care Hospital,Jining,Shandong,China 272100;2.Yutai County Maternal and Child Health Care Hospital,Jining,Shandong,China 272300) |
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| Abstract: | Objective To establish a HPLC method for the determination of forsythin in Compound Qinlan Oral Liquid.Methods The method was performed on the C 18 column（250 mm × 4.6 mm,5 μm）,with the mobile phase consisting of acetonitrile-water（25 ∶ 75）.The flow rate was 1.0 mL / min and the detection wavelength was set at 278 nm.Results The linear range of forsythin was 1.22 12.2 μg,r = 0.999 5 and the average recovery rate was 98.66%,RSD = 0.72%（n = 6）.Conclusion The established method is simple,accurate and better repeatable,which can be used for the quality control of this preparation. |
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| Keywords: | HPLC Compound Qinlan Oral Liquid forsythin content determination |
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