| 鱼藤酮和MPTP慢性帕金森病小鼠黑质共同差异蛋白研究 |
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| 引用本文： | 周长青,杨旭,杨云鹏,万金城,赵臣勇,彭国光.鱼藤酮和MPTP慢性帕金森病小鼠黑质共同差异蛋白研究[J].第三军医大学学报,2011,33(14):1432-1436. |
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| 作者姓名： | 周长青 杨旭 杨云鹏 万金城 赵臣勇 彭国光 |
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| 作者单位： | 重庆医科大学附属第一医院神经内科,重庆,400016 |
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| 基金项目： | 国家自然科学基金(30370499)~~ |
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| 摘 要： | 目的 通过比较鱼藤酮和1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)两种慢性帕金森病(Parkinson's disease,PD)模型小鼠与对照组小鼠黑质蛋白表达谱,找出两种PD模型小鼠共同的差异蛋白,探索筛选出PD的...
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| 关 键 词： | 慢性帕金森病小鼠模型 蛋白质组学 疾病特异性蛋白 |
Common differentially expressed proteins in substantia nigra of mouse models with chronic Parkinson's disease induced by rotenone and MPTP |
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| Zhou Changqing,Yang Xu,Yang Yunpeng,Wan Jincheng,Zhao Chenyong,Peng Guoguang.Common differentially expressed proteins in substantia nigra of mouse models with chronic Parkinson's disease induced by rotenone and MPTP[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(14):1432-1436. |
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| Authors: | Zhou Changqing Yang Xu Yang Yunpeng Wan Jincheng Zhao Chenyong Peng Guoguang |
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| Affiliation: | Zhou Changqing,Yang Xu,Yang Yunpeng,Wan Jincheng,Zhao Chenyong,Peng Guoguang(Department of Neurology,First Affiliated Hospital,Chongqing Medical University,Chongqing,400016,China) |
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| Abstract: | Objective To search for the common differentially expressed proteins in the substantia nigra of mouse models with Parkinson's disease(PD) induced by rotenone and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),and to screen out the disease-specific proteins(DSPs) of PD.Methods Forty-eight mice were randomly divided into a rotenone group and its control group 1,as well as an MPTP group and its control group 2.In the rotenone group and MPTP group,rotenone and MPTP were given separately by injection to cons... |
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| Keywords: | chronic mouse models of Parkinson's disease proteomics disease-specific proteins |
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