| 血凝素样氧化型低密度脂蛋白受体-1与动脉粥样硬化 |
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| 引用本文： | 李东升,刘运海. 血凝素样氧化型低密度脂蛋白受体-1与动脉粥样硬化[J]. 国际脑血管病杂志, 2008, 16(12): 939-942 |
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| 作者姓名： | 李东升 刘运海 |
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| 作者单位： | 中南大学湘雅医院神经内科,长沙,410008 |
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| 摘 要： | 血凝素样氧化型低密度脂蛋白受体-1(LOX-1)是由内皮细胞表达的氧化低密度脂蛋白(oxLDL)的特异性受体,是一种Ⅱ型单链跨膜蛋白,属C型血凝素家族.LOX-1通过介导oxLDL导致血管内皮细胞损伤,参与动脉粥样硬化、高血压、血栓形成等疾病的形成和发展过程.文章就LOX-1与动脉粥样硬化的关系做了综述.
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| 关 键 词： | 血凝素样氧化型低密度脂蛋白受体-1 氧化型低密度脂蛋白 动脉粥样硬化 基因多态性 |
Lectin-Like Oxidized Low-Density-Lipoprotein Receptor-1 and Atherosclerosis |
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| Dong-Sheng Li,Yun-Hai Liu. Lectin-Like Oxidized Low-Density-Lipoprotein Receptor-1 and Atherosclerosis[J]. International Journal of Cerebrovascular Diseases, 2008, 16(12): 939-942 |
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| Authors: | Dong-Sheng Li Yun-Hai Liu |
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| Abstract: | Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a specific receptor of oxidized low-density lipoprotein (oxLDL) expressed in endothelial cells. It is a type Ⅱ single-chain transmembrane protein and belongs to C-type lectin family. LOX-1 leads to the injury of endothelial cells by mediating oxLDL, and plays a role in the initiation and progression of atherosclerosis, hypertension, thrombosis. This article reviews the association between LOX-1 and atherosclerosis. |
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| Keywords: | lectin-like oxidized low-density lipoprotein receptor-1 oxidized low-density lipoprotein atherosclerosis gene polymorphism |
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