Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo |
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| Authors: | Meerovich Irina G Jerdeva Victoriav Derkacheva Valentina M Meerovich Gennady A Lukyanets Eugeny A Kogan Eugenia A Savitsky Alexander P |
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| Affiliation: | Laboratory of Physical Biochemistry, A.N.Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospect, Moscow. |
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| Abstract: | The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis. |
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