扩散峰度成像在正常成人视通路中的应用研究

目的 应用扩散峰度成像(DKI)定量测量正常成人视通路各区域的平均峰度(MK)值、部分各向异性(FA)值和平均扩散率(MD), 探讨DKI技术在正常成人视通路研究中的应用价值。 方法 按区组随机化选择30名正常成人志愿者, 按年龄分为3组:20~39岁组、40~59岁组和60岁以上组, 每组10名, 均行常规颅脑MR和DKI序列扫描, 并测量视通路不同区域的MK值、FA值和MD, 采用SPSS15.0统计学软件分析MK值、FA值和MD的正常范围, 及其随年龄递增的变化规律。 结果 视神经、外侧膝状体、视放射和视皮层区域MK值与年龄呈负相关; 外侧膝状体、视放射区域FA值与年龄呈负相关; 视神经、外侧膝状体区域MD与年龄呈正相关。 结论 DKI所得参数可以无创性地反映正常成人视通路随年龄增长的微观结构的变化。

Application study of diffusion kurtosis imaging in normal adult visual pathway

Objective To explore the application value of diffusion kurtosis imaging(DKI) in normal adult visual pathway in the change of mean kurtosis (MK),fractional anisotropy (FA),and mean diffusion (MD) coefficient.Methods DKl was used to measure MK,FA and MD in different regions of the normal adult visual pathway of 10 young aduhs(20 years to 39 years),10 middle-aged adults (40 years to 59 years),and 10 senior aduhs(＞60 years).The normal range of MK,FA and MD values and its variation with increasing age were analyzed using SPSS 15.0 statistical analysis software.Results The MK values of the optic nerve,lateral geniculate nucleus,optic radiation,and optic cortex were significantly different and negatively correlated.The FA values of the lateral geniculate nucleus and optic radiation were significantly different and negatively correlated.The MD values of the optic nerve and lateral geniculate nucleus were significantly different and positively correlated.Conclusion The DKI parameters can non-invasively reflect the changes in the microstructure of the normal adult visual pathway.