慢性阻塞性肺疾病与病毒感染关系的研究

目的 观察慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者病毒感染状况,并探讨病毒感染与COPD的关系.方法 选择2012年1月-2014年10月就诊的COPD急性发作患者320例(A组),COPD稳定期患者105例(B组)、健康体检者56例为C组,分别检测腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(Flu A virus)、流感病毒B(Flu B virus)、副流感病毒(Parainfluenza virus)、柯萨奇病毒A(COXA)、柯萨奇病毒B(COXB)、埃可病毒(ECA)特异性抗体IgM,并组间进行比较.结果 COPD急性发作组患者8种呼吸道病毒的总感染率为32.8％,明显高于稳定期患者和健康体检者,存在显著差异(P＜0.05).结论 呼吸道病毒感染是COPD急性加重的重要原因,应引起重视.

Study on the relation between chronic obstructive lung disease and infection viral

Objective To explore the infection status of chronic obstructive pulmonary disease cases (COPD), and study on the relation between chronic obstructive lung disease and infection viral.Methods 320 COPD cases of acute episode were included in group A from January 2012 to October 2014.105 cases of stable phase were included in group B.56 people healthy examined were included in group C.Antibodies IgM of ADV, RSV, Flu A virus, Flu A virus, Parainfluenza virus, COXA, COXB and ECA were detected.The data was compared among different groups.Results The overall infection rate of 8 kinds virus was 32.8％ in COPD cases of acute episode.Positive rate of A group was high than B and C group (P ＜0.05).Conclusions Respiratory virus infection was one of the main reasons of COPD exacerbation.We should pay more attention to this result.