疏风饮抗I型超敏反应实验研究

目的研究疏风饮抗I型超敏反应的作用机制。方法应用卵白蛋白造成I型超敏反应动物模型，采用ELISA法测定疏风饮对大鼠血清中白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）及免疫球蛋白E（IgE）含量的影响。结果疏风饮可增加模型大鼠血清IFN-γ含量（P〈0．05），降低模型大鼠血清IL-4、IgE含量（P〈0．01）。疏风饮组和扑尔敏组比较无显著差异（P〉0．05）；疏风饮组IFN-γ／IL-4高于模型组，有显著差异（P〈0．05），而和扑尔敏组比较无显著差异（P〉0．05）。结论疏风饮防治皮肤I型超敏反应性疾病（急性荨麻疹）的作用机制可能与其通过对某些细胞因子的调节，对机体内Th1／Th2平衡产生影响有关。

Experimental Study of Shufeng Decoction on Resisting Type I Hypersensitivity

Objective To investigate the effects and mechanism of Shufeng Decoction resisting type I hypersensitivity. Methods Type I hypersensitivity was induced by OVA. The content of IL-4, IFN-γ and IgE in serum of the rats treated by Shufeng Decoction were determined by ELISA. Results Shufeng Decoction can increase the content of IFN-γ in model rats （P〈0.05）, and decrease the content of IL-4 and IgE （P〈0.01）, there was no significant difference between Shufeng Decoction group and chlorpheniramine group （P〉0.05）. IFN-γ/IL-4 of Shufeng Decoction was significant higher than model group （P〈0.05）, and there was no significant difference compared with chlorpheniramine group （P〉0.05）. Conclusion The effects and mechanism of Shufeng Decoction on prophylaxis and treatment of type I hypersensitivity of skin （acute urticaria） may be related with regulating cell factors and influencing the balance of Th1/Th2.