| 脂肪酸合成在利福平引起小鼠肝脏脂肪变性中的作用 |
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| 引用本文： | 张莹,段自皞,陈熙,张程,徐德祥. 脂肪酸合成在利福平引起小鼠肝脏脂肪变性中的作用[J]. 安徽医科大学学报, 2011, 46(7): 648-651 |
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| 作者姓名： | 张莹 段自皞 陈熙 张程 徐德祥 |
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| 作者单位： | 安徽医科大学卫生毒理学系,合肥,230032;安徽医科大学卫生毒理学系,合肥,230032;安徽医科大学卫生毒理学系,合肥,230032;安徽医科大学卫生毒理学系,合肥,230032;安徽医科大学卫生毒理学系,合肥,230032 |
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| 基金项目： | 国家自然科学基金，安徽省自然科学基金 |
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| 摘 要： | 目的 研究利福平(RIF)引起小鼠肝脏发生脂肪变性的作用机制.方法 将雌性ICR成年健康小鼠随机分为对照组和RIF组,分别灌胃给予等量的生理盐水或RIF(200 mg/kg),连续处理1周及单次处理.分析血清和肝脏中甘油三酯(TG)水平,油红O染色观察肝脏脂肪聚集情况,RT-PCR法检测肝脏脂肪酸合成酶(Fasn)、乙...
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| 关 键 词： | 利福平 肝 脂肪酸类 |
The role of synthesis of fatty acids on rifampicin arosing the steatosis in mice liver |
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| Zhang Ying,Duan Zihao,Chen Xi,et al. The role of synthesis of fatty acids on rifampicin arosing the steatosis in mice liver[J]. Acta Universitis Medicinalis Anhui, 2011, 46(7): 648-651 |
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| Authors: | Zhang Ying Duan Zihao Chen Xi et al |
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| Affiliation: | Zhang Ying,Duan Zihao,Chen Xi,et al(Dept of Toxicology,Anhui Medical University,Hefei 230032) |
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| Abstract: | Objective To investigate the mechanism of rifampicin(RIF) arose steatosis in mouse liver.Methods ICR female mice were divided into the control group and the RIF group.Who were respectively administered with saline or RIF(200 mg/kg)daily by gavage for one week or a single day.Assays for triglyceride(TG)was performed to assess liver steatosis.The lipid accumulation of liver was observed by oil red O staining.The expressions of fatty acid synthetase(Fasn),acetyl-CoA catboxylase(Acc),stearoyl-CoA desaturase 1(S... |
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| Keywords: | rifampicin liver fatty acids |
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