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| 丙型肝炎病毒感染慢性化机制研究进展 | |
| 引用本文： | 程广霞,杨玉然,张玲.丙型肝炎病毒感染慢性化机制研究进展[J].医学综述,2008,14(24):3740-3743. |
| 作者姓名： | 程广霞 杨玉然 张玲 |
| 作者单位： | 1. 山东省医学科学院基础医学研究所,山东省肿瘤免疫与中药免疫重点实验室,山东省现代医用药物与技术重点实验室,济南250062;济南市传染病医院检验科,济南,250021 2. 济南市传染病医院检验科,济南,250021 3. 山东省医学科学院基础医学研究所,山东省肿瘤免疫与中药免疫重点实验室,山东省现代医用药物与技术重点实验室,济南250062 |
| 摘 要： | 丙型肝炎是由丙型肝炎病毒(HCV)感染所致的一种世界范围的疾病,绝大多数发展为慢性持续性感染,并最终进展为肝硬化和肝细胞癌。其慢性化的机制非常复杂,是由多个因素造成的,HCV因其基因高变性可以逃避宿主的免疫监视;HCV具有泛嗜性,肝外组织又可为肝组织的反复感染提供病毒来源;CD81、LDL受体、清道夫受体B类Ⅰ型及L-SIGN、DC-SIGN等HCV受体又可不同程度地影响机体的体液免疫和细胞免疫功能;HCV感染亦可直接导致机体免疫细胞数量减少或功能缺陷,体液免疫应答水平低下、细胞免疫耐受,宿主最终转变为慢性感染状态。 |
| 关 键 词： | 丙型肝炎病毒 慢性化 变异 受体 免疫应答 |
Research Progress about Chronicity Mechanism of Hepatitis C Virus Infection |
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| CHENG Guang-xia,YANG Yu-ran,ZHANG Ling.Research Progress about Chronicity Mechanism of Hepatitis C Virus Infection[J].Medical Recapitulate,2008,14(24):3740-3743. | |
| Authors: | CHENG Guang-xia YANG Yu-ran ZHANG Ling |
| Affiliation: | 1.Institute of Basic Medicine;Shandong Academy of Medical Science;Key Medical Laboratory for Tumor Immunology and Chinese Medicine Immunology of Shandong Province;Key Laboratory of Modern Medicine and Technology of Shandong province;Jinan 250062;China;2.Department of Laboratory;Jinan Hospital for Infectious Diseases;Jinan 250021;China |
| Abstract: | Hepatitis C is a worldwide disease that is caused by Hepatitis C Virus (HCV),the overwhelming majority will develop into the chronic persistence infection,and finally progress into liver cirrhosis and hepatocellular carcinoma.Chronicity maybe result from many factors with complex mechanism.HCV may evade the host immune surveillance due to the hypermutation of HCV gene; HCV has the nature of pantropic,the tissues outside liver can provide virus for repeatedly infection of liver; The HCV receptors,such as CD8... |
| Keywords: | Hepatitis C virus Chronicity Variation Receptor Immune response |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
