盐酸林可霉素的萃取与结晶提纯

为了降低盐酸林可霉素粗品中的B组分含量，采用萃取与结晶相结合的方法，分别研究了萃取结晶过程中萃取剂种类、用量、原料浓度、溶液pH等条件以及溶析结晶过程中的混合速率对产品纯度的影响。结果表明：丁醇或氯仿有较高的萃取效率；降低原料浓度或在萃取、反萃时分别保持溶液pH为11和5均有利于提高产品中的A组分含量；结晶过程中提高搅拌速率有利于提高产品纯度。以氯仿为萃取剂，经过单级萃取，结晶后产品中A组分纯度最高可达97.86%。

Purification of Hydrochloride Lincomycin by Solvent Extraction and Crystallization

To lower the content of component B in the crude lincomycin product, by means of solvent extraction combined with solvent out crystallization, the influences of solvent, phase ratio, concentration of raw material, pH and the rate of mixing on the product purity were investigated. n-Butanol and chloroform were found to have better performance than n-pentanol, iso-pentanol, n-octanol and the mixture of chloroform with iso-pentanol or n-octanol. During extraction and reverse extraction the pH were adjusted to 11 and 5, respectively. Increasing the rate of mixing during the crystallization was helpful to increase the product purity. After one stage extraction the purity of component A in the final product was 97.86%.