140例特发性肺纤维化患者中医证型分布及相关因素分析

目的:分析140例特发性肺纤维化患者中医证型分布,并观察各证候间相关指标的差异性.方法:采集患者四诊信息,运用K-均值聚类分析法对纳入患者的四诊信息进行聚类分析;获取相关临床指标,如血常规、红细胞沉降率(ESR)、C-反应蛋白(CRP)、D-二聚体、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、细胞角蛋白19片段...

Analysis on the Distribution of Traditional Chinese Medicine Syndromes and Related Factors in 140 Patients with Idiopathic Pulmonary Fibrosis

Objective:To analyze the distribution of traditional Chinese medicine(TCM) syndromes in 140 patients with idiopathic pulmonary fibrosis,and to investigate the differences on clinical indexes between different syndrome types. Methods:The four diagnostic information was collected and analyzed using the K-mean clustering analysis. Clinical data were obtained,including the value of routine blood test(RBT),erythrocyte sedimentation rate(ESR),levels of C-reactive protein(CRP),D-dimer,neuron-specific enolase(NSE),carcinoembryonic antigen(CEA),cytokeratin 19 fragment( CY21-1), the first second forced expiratory volume( FEV1), forced expiratory volume( FVC),carbon monoxide diffusion volume(DLCO),and the major indicators of arterial blood gas analysis.One-way analysis of variance,non-parametric test,and other methods were applied to analyze the differences on these data between different syndrome types. Results:There were 140 cases included,and five types were clustered:15 cases of deficiency of qi and yin(10.7%),18 cases of yin deficiency and blood stasis(12.9%),23 cases of yang deficiency of spleen and kidney(16.4),27 cases of yin deficiency and phlegm fever(19.3%),and yin deficiency with dampness(40.7%). The blood oxygen saturation(SaO2) in yang deficiency of spleen and kidney group and deficiency of qi and yin group was lower than that in yin deficiency and phlegm fever group,with statistical difference(P<0.05). The arterial partial pressure of oxygen(PaO2) in yang deficiency of spleen and kidney group and deficiency of qi and yin was lower than that in yin deficiency with dampness group(P<0.05). Conclusion:There are five common types of IPF:deficiency of qi and yin,yin deficiency and blood stasis,yang deficiency of spleen and kidney,yin deficiency and phlegm fever,and yin deficiency with dampness. The low-level PaO2 and SaO2 imply deficiency of healthy qi.