| 金属蛋白酶及其组织抑制剂在涎腺腺样囊性癌细胞株表达的 … |
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| 引用本文： | 史宏男,何荣根.金属蛋白酶及其组织抑制剂在涎腺腺样囊性癌细胞株表达的 …[J].中华口腔医学杂志,1997,32(6):323-326. |
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| 作者姓名： | 史宏男 何荣根 |
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| 摘 要： | 为了研究金属蛋白酶（ｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ，ＭＭＰ）及其组织抑制剂（ｔｉｓｓｕｅｉｎｈｉｂｉｔｏｒｏｆｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ，ＴＩＭＰ）对涎腺腺样囊性癌细胞（ａｄｅｎｏｉｄｃｙｓｔｉｃｃａｒｃｉｎｏｍａ，ＡＣＣ）转移的影响，本研究应用斑点印迹杂交的分子生物学方法检测ＡＣＣ－２细胞系及高转移细胞株ＡＣＣ－Ｍ中ＭＭＰ－２，ＭＭＰ－９和ＴＩＭＰ－２的表达，结果显示，ＭＭＰ－２，Ｍ
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| 关 键 词： | 涎腺肿瘤 肿瘤转移 金属蛋白酶 组织抑制剂 |
Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma] |
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| H Shi,R He,X Zhou.Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma][J].Chinese Journal of Stomatology,1997,32(6):323-326. |
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| Authors: | H Shi R He X Zhou |
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| Affiliation: | School of Stomatology, Shanghai Second Medical University, Shanghai 200011. |
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| Abstract: | In order to research the relation between metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) and metastasis of salivary adenoid cystic carcinoma (ACC). We use dot blotting to analyse the expression of MMP-2, MMP-9 and TIMP-2 in ACC-2, a cell line of ACC in palate and ACC-M, a high lung metastasis clone which cloned from ACC-2. The result showed the expression of MMP-2 and MMP-9 were higher in ACC-M than that in ACC-2, but the expression of TIMP-2 were higher in ACC-2 than that in ACC-M This suggest MMP-2 and MMP-9 can promote ACC metastasis, TIMP-2 can suppress ACC metastasis. MMP and TIMP maybe a key mechanism of ACC metastasis. |
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