尿多酸肽对乳腺癌细胞凋亡的影响

目的研究肿瘤细胞分化诱导剂尿多酸肽（CDA—Ⅱ）对乳腺癌细胞凋亡的影响。方法将CDA—Ⅱ与不同生物学特性的乳腺癌细胞株MCF-7和MDA-MB-231进行体外培养，同时以维甲酸为阳性对照，观察CDA—Ⅱ对乳腺癌细胞生长曲线、细胞凋亡及形态学等方面的影响。结果CDA—Ⅱ可减缓两株乳腺癌细胞的生长和增殖能力，诱导乳腺癌细胞凋亡。结论CDA—Ⅱ可抑制MCF-7和MDA-MB-231两株乳腺癌细胞的生长和增殖能力，诱导乳腺癌细胞凋亡．本研究为CDA-Ⅱ治疗乳腺痛提供了实验依据。

Effect of uroacitides on apoptosis of breast cancer cells

Objective To investigate the effect of CDA-II on apoptosis of breast cancer cells. Methods The effects of CDA-II on growth curve, cell apoptosis and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed by in vitro cultures, and compared with the classical cell differentiation inducer ATRA. MCF-7 and MDA-MB-231 cell lines have their different biologic characteristics. Results CDA-II can reduce growth and proliferation ability and induce cell apoptosis of breast cancer cell lines( MCF-7 and MDA-MB-231). Conclusions CDA-II has remarkable effect of anti-cell-proliferation and induction of (apoptosis) on breast cancer cells MCF-7 and MDA-MB-231 . Our results provide experimental bases for the treatment of breast carcinoma with CDA-II.