| 抗人膀胱癌/抗VEGF双功能基因抗体导入治疗荷瘤鼠膀胱癌的研究 |
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| 引用本文： | 任明,刘禄成,范海涛,朱德淳,李然伟,李香云.抗人膀胱癌/抗VEGF双功能基因抗体导入治疗荷瘤鼠膀胱癌的研究[J].中国免疫学杂志,2003,19(12):859-860,864. |
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| 作者姓名： | 任明 刘禄成 范海涛 朱德淳 李然伟 李香云 |
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| 作者单位： | 吉林大学第二医院泌尿外科,长春,130041 |
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| 基金项目： | 国家自然科学基金资助项目 (编号 3 0 170 940 ) |
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| 摘 要： | 目的：探讨抗人膀胱癌，抗VEGF双功能基因抗体对膀胱癌生长的抑制作用。方法：应用双功能抗体作用荷瘤鼠模型，观察抑瘤作用；应用免疫组化技术检测体内生长肿瘤中微血管密度。结果：双功能抗体对体内生长的肿瘤有明显的抑制作用，经双功能抗体治疗的瘤体中微血管密度明显低于对照组。结论：双功能抗体可以抑制肿瘤血管生成，有望为膀胱癌的治疗提供新的方法。
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| 关 键 词： | 双功能抗体 微血管密度 免疫组织化学 |
| 文章编号： | 1000-484X(2003)12-0859-03 |
The effect of bispecific antibody(BsAb,anti-human bladder cancer/anti-VEGF) on cancer bearing mice |
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| REN Ming,LIU Lu-Cheng,FAN Hai-Tao et al.The effect of bispecific antibody(BsAb,anti-human bladder cancer/anti-VEGF) on cancer bearing mice[J].Chinese Journal of Immunology,2003,19(12):859-860,864. |
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| Authors: | REN Ming LIU Lu-Cheng FAN Hai-Tao |
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| Affiliation: | REN Ming,LIU Lu-Cheng,FAN Hai-Tao et al.Department of Urology,the Second Hospital of Jilin University,Changchun 130041,China |
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| Abstract: | Objective:To study the inhibitory role of BsAb(anti-human bladder cancer/anti-VEGF) on human bladder cancer growth.Methods:BsAb was used to treat animal models of BIU-87 cell lines.The tumor inhibition rate was calculated and the tumor microvessel density was detected by immunohistochemical techniques.Results:BsAb could significantly inhibit growth of tumor.And the tumor microvessel density was lower than that of the control group.Conclusion:BsAb could inhibit tumor growth by inhibiting angiogenesis. BsAb may become a new method for human bladder cancer treatment. |
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| Keywords: | Bispecific antibody Microvessel density Immunohistochemistry |
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