| 甲状腺乳头状癌中BRAF V600E突变及其与甲状腺超声表现的关系 |
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| 引用本文： | 林伟,石建华,宋怀东,项平,汪万英,张筱华.甲状腺乳头状癌中BRAF V600E突变及其与甲状腺超声表现的关系[J].蚌埠医学院学报,2010,35(12):1220-1222. |
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| 作者姓名： | 林伟 石建华 宋怀东 项平 汪万英 张筱华 |
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| 作者单位： | 蚌埠医学院第一附属医院,内分泌科,安徽,蚌埠,233004;上海交通大学附属瑞金医院,人类基因组国家重点实验室,上海,200025;蚌埠医学院第一附属医院,中心实验室,安徽,蚌埠,233004;温州医学院附属第一医院,肿瘤外科,浙江,温州,325000 |
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| 基金项目： | 安徽省教育厅自然科学研究重点资助项目 |
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| 摘 要： | 目的：探讨甲状腺乳头状癌（papillary thyroid carcinoma,PTC）中BRAF V600E突变及其与甲状腺超声表现的关系。方法：采用PCR反应扩增及DNA直接测序法检测34例PTC患者手术切除的新鲜甲状腺组织及其癌旁组织的BRAF V600E突变情况,比较PTC发生和未发生BRAF V600E突变患者的甲状腺超声检查影像。结果：34例PTC癌组织标本中有18例发生BRAF V600E突变,16例未发生突变;34例PTC癌旁组织标本均未检测到BRAF V600E突变。PTC BRAF V600E突变患者与未发生突变患者甲状腺超声检查的癌块大小、边界是否清楚及有无钙化差异均无统计学意义（P〉0.05）。结论：PTC中BRAFV600E突变率较高;BRAF V600E突变与甲状腺超声表现无明显关系。甲状腺超声表现不能预测PTC中BRAF V600E突变的存在。
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| 关 键 词： | 甲状腺肿瘤 乳头状瘤 BRAF 超声检查 |
Correlation between BRAF V600E mutation in papillary thyroid carcinoma and the sonographic findings |
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| LIN Wei,SHI Jian-hua,SONG Huai-dong,XIANG Ping,WANG Wan-ying,ZHANG Xiao-hua.Correlation between BRAF V600E mutation in papillary thyroid carcinoma and the sonographic findings[J].Journal of Bengbu Medical College,2010,35(12):1220-1222. |
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| Authors: | LIN Wei SHI Jian-hua SONG Huai-dong XIANG Ping WANG Wan-ying ZHANG Xiao-hua |
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| Affiliation: | LIN Wei1,SHI Jian-hua1,SONG Huai-dong2,XIANG Ping3,WANG Wan-ying4,ZHANG Xiao-hua5(1.Department of Endocrinology,3.Central Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,2.State Key Laboratory of Human Gene,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,4.Department of Surgical Oncolgy,The First Affiliated Hospital of Wenzhou Medical College,Zhejiang Wenzhou 325000,China) |
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| Abstract: | Objective:To observe the relationship between BRAF V600E mutation in papillary thyroid carcinoma(PTC) and the sonographic findings.Methods:The study included 34 fresh PTC tissue samples and the neighboring tissues from the patients surgically confirmed PTC.The BRAF V600E mutation of all the cases was determined by allelespecific polymerase chain reaction and direct DNA sequencing.The ultrasound findings were compared between the nodules with and without mutation.Results:Of the 34 carcinoma samples,BRAF V600... |
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| Keywords: | thyroid neoplasms papilloma BRAF sonographic findings ultrasonography |
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