| 茶多酚和粉防己碱联合抗肿瘤药物对鼻咽癌耐药细胞株HNE-1(200)增殖的抑制作用 |
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| 引用本文： | 王洪鹏,叶琳,王驰,陈鸿雁.茶多酚和粉防己碱联合抗肿瘤药物对鼻咽癌耐药细胞株HNE-1(200)增殖的抑制作用[J].中国中医急症,2010,19(1):102-103,108. |
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| 作者姓名： | 王洪鹏 叶琳 王驰 陈鸿雁 |
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| 作者单位： | 1. 重庆医科大学附属第一医院,重庆,400016
2. 重庆医科大学药学院,重庆,400016 |
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| 基金项目： | 重庆市卫生局资助课题 |
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| 摘 要： | 目的研究天然有效成分茶多酚(TP)和粉防己碱(TET)分别联合4种常见抗肿瘤药物对鼻咽癌耐药细胞株HNE-1(200)增殖的抑制作用。方法以鼻咽癌耐药细胞株HNE-1(200)为研究对象,用MTT法测定无毒剂量的TP和TET分别联合顺铂(DDP)、5-氟尿嘧啶(5-Fu)、长春新碱(VCR)、阿霉素(ADM)对实验细胞的增殖抑制率。结果无毒剂量的TP分别与4种抗肿瘤药物联合应用后,药物对HNE-1(200)细胞的抑制率增加约200%;无毒剂量的TET分别与4种抗肿瘤药物联合应用后,药物对HNE-1(200)细胞的抑制率增加约300%。结论无毒浓度的天然药物TP、TET分别与抗肿瘤药物联合应用能提高药物对鼻咽癌耐药细胞株的增殖抑制率,降低药物的IC50。
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| 关 键 词： | 茶多酚 粉防己碱 鼻咽癌 HNE-1（200）细胞系 多药耐药 |
Study of the Inhibitive Effects of Tea Polyphenols and Tetrandrine Combined with Antineoplastic Drugs on the HNE-1 (200) Cell Line |
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| WANG Hong-peng,YE Lin,WANG Chi,et al The First Affiliated Hospital,Chongqing Medical University Chongqing Medical University.Study of the Inhibitive Effects of Tea Polyphenols and Tetrandrine Combined with Antineoplastic Drugs on the HNE-1 (200) Cell Line[J].Journal of Emergency in Traditional Chinese Medicine,2010,19(1):102-103,108. |
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| Authors: | WANG Hong-peng YE Lin WANG Chi The First Affiliated Hospital Chongqing Medical University Chongqing Medical University |
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| Affiliation: | WANG Hong-peng1,YE Lin1,WANG Chi2,et al 1 The First Affiliated Hospital,Chongqing Medical University ( Chongqing 400016) 2 Chongqing Medical University ( Chongqing 400016) |
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| Abstract: | Objective:To obverse the inhibitive effects of tea polyphenols and tetrandrine apiece combined with 4 kinds of antineoplastic drugs on the HNE-1 (200) cell line. Methods: MTT method was used to determine the inhibitory proliferation effects of non-toxic dose tea polyphenols and tetrandrine apiece combined with DDP, 5-Fu, VCR and ADM on HNE-1 (200) cell line. Results: Non-toxic dose tea polyphenols combined with 4 kinds of antineoplastic drugs could increase the inhibitory rate to 200% . Non-toxic dose tetra... |
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| Keywords: | Teapolyphenols Tetrandrine Nasopharyngealcarcinoma HNE-1 (200) cellline Multidrugresistance |
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