益气健脾汤联合香菇多糖治疗高危乳腺癌患者的疗效观察

目的:观察益气健脾汤联合香菇多糖治疗高危乳腺癌患者的疗效。方法:选取2016年2月至2018年2月广州中医药大学祈福医院收治的高危乳腺癌患者97例作为研究对象,按照随机数字表法随机分为对照组(n=48)和观察组(n=49)。对照组采用常规化疗,观察组在对照组基础上给予益气健脾汤联合香菇多糖治疗,比较2组患者临床疗效、T淋巴细胞亚群、炎性反应因子、肿瘤转移浸润因子水平及不良反应发生情况。结果:治疗后,观察组临床总有效率高于对照组(63.26%vs41.67%)(P<0.05);2组患者CD8+升高,但观察组低于对照组(P<0.05);CD3+、CD4+、CD4+/CD8+均下降,但观察组高于对照组(均P<0.05);2组患者白细胞介素-17(IL-17)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子-A(VEGF-A)、转化生长因子-β(TGF-β)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶组织抑制剂-1(TIMP-1)水平均较治疗前下降,且观察组低于对照组(P<0.05)。2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:常规化疗基础予以益气健脾汤联合香菇多糖治疗可提高高危乳腺癌的临床疗效,改善患者免疫功能、降低炎性反应因子水平、减轻肿瘤转移浸润风险。

Observation of Therapeutic Effects of Yiqi Jianpi Decoction Combined with Lentinan on Patients with High-risk Breast Cancer

Objective:To observe the therapeutic effects of Yiqi Jianpi Decoction combined with lentinan in patients with high-risk breast cancer.Methods:A total of 97 patients with high-risk breast cancer who were admitted to Clifford Hospital of Guangzhou University of Chinese Medicine from February 2016 to February 2018 were selected as the research objects,and were divided into a control group(n=48)and a study group(n=49)according to random number table method.The control group used conventional chemotherapy,and the observation group was given Yiqi Jianpi Decoction combined with lentinan Clinical efficacy,T lymphocyte subsets,inflammatory factors,tumor metastasis and infiltration factors and adverse reactions were compared.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(63.26%vs 41.67%);the levels of CD8+in the 2 groups increased,but that in the study group was lower than that in the control group(P<0.05);the levels of CD3+,CD4+,CD4+/CD8+in the 2 groups all decreased,but those in the study group were higher than those in the control group(all P<0.05);the levels of interleukin-17(IL-17),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),vascular endothelial growth factor-A(VEGF-A),transforming growth factor-β(TGF-β),matrix metalloproteinase-2(MMP-2),tissue inhibitor of matrix metalloproteinase-1(TIMP-1)in the 2 groups were lower those before treatment,and those in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Yiqi Jianpi Decoction combined with lentinan on the basis of conventional chemotherapy can improve therapeutic effects,effectively improve the immune function,reduce the level of inflammatory factors,and reduce the risk of metastasis and infiltration of tumors.