Influence of phytosterol and phytostanol food supplementation on plasma liposoluble vitamins and provitamin A carotenoid levels in humans: An updated review of the evidence |
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Authors: | Anthony Fardet Anne Morise Esther Kalonji Irène Margaritis François Mariotti |
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Affiliation: | 1. INRA, JRU 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand &2. Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France;3. ANSES, Unité d'Evaluation de Risques liés à la Nutrition, Maison-Alfort, France;4. AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France;5. INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France |
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Abstract: | Phytosterols and phytostanols (PAP) compete with cholesterol absorption in the intestine, resulting in a 5–15%-reduction in plasma total and LDL cholesterol. An important issue is the PAP potential to reduce the plasma concentrations of fat-soluble vitamins and provitamin A carotenoids. Here, an update of the scientific evidence is reviewed to evaluate plant PAP-enriched foods impact on plasma fat-soluble vitamins and carotenoid levels, and to discuss potential implications in terms of cardiovascular risk. Based on 49 human interventional and 3 bioavailability studies, results showed that regular consumption, particularly over the long term, of foods fortified with PAP as recommended in labeling does not significantly impact plasma vitamins A, D, and K concentration. A 10% significant median reduction was observed for α-tocopherol. Concerning carotenoids, while 13 studies did not demonstrate statistically significant plasma β-carotene reduction, 20 studies showed significant reductions, with median effect size of ?24%. This decline can be mitigated or offset by increased fruits and vegetables consumption. Furthermore, higher cardiovascular risk was observed for differences in plasma β-carotene concentration of the same magnitude as the estimated average decrease by PAP consumption. These results are supported by the only study of β-carotene bioavailability showing decrease in absorption by phytosterols daily intake. |
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Keywords: | Phytosterol and phytostanol-enriched foods liposoluble vitamins provitamin A carotenoids intervention studies cardiovascular disease risk |
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