左心室舒张功能减低是青年高血压病患者罹患脑梗死的独立预测因素——一项回顾性调查研究

目的探讨左心室舒张功能减低与青年高血压病患者急性脑梗死的相关性。方法收集2014年10月~2018年2月宝鸡市第二中医医院神经内科收治的青年急性脑梗死同时患有高血压病的患者92例(观察组),同时选取同期患有高血压病的青年体检患者98例(对照组)。对两组患者都进行心脏彩色多普勒检査,观察患者的左心室舒张功能,并分析左心室舒张功能减低与急性脑梗死的关系。结果190例青年高血压病患者中,左心室舒张功能正常者18例,占9.47%,左心室舒张功能减低者172例,占90.53%,其中127例为左心室舒张功能减低1级,占66.84%(127/190),55例为左心室舒张功能2级,占28.95%(55/190),8例为左心室舒张功能3级,占4.21%(8/190)o观察组患者IVRT,Ea/Aa及A'值分别为(114.97±10.16)J0.79±0.11)和(5.21±1.03),对照组分别为(72.86±8.75)、(1.3士0.25)和(5.02±0.82),差异有统计学意义(P<0.05)0观察组患者左心室舒张功能减低IVRT、Ea/Aa及A'值和急性脑梗死发生之间有相关关系(r=0.53,r=0.61,r=-0.59)。结论青年左心室舒张功能减低与高血压病有关,左室舒张功能减低可能是青年高血压病患者罹患急性脑梗死的独立预测因素。

Left ventricular diastolic dysfunction is an independent predictive factor for cerebral infarction in young hypertensive patients: A retrospective study

Objective To investigate the association between left ventricular diastolic dysfunction and acute cerebral infarction in young patients with hypertension.Methods A total of 92 young patients with acute cerebral infarction and hypertension who were admitted to Department of Neurology in Baoji Second Hospital of Traditional Chinese Medicine from October 2014 to February 2018 were enrolled as observation group, and 98 young patients with hypertension who underwent physical examination during the same period of time were enrolled as control group. Heart color Doppler was performed for both groups to observe left ventricular diastolic function and analyze the association between left ventricular diastolic dysfunction and acute cerebral infarction.Results Among the 190 young patients with hypertension, 18 (9.47%) had normal left ventricular diastolic function and 172 (90.53%) had reduced left ventricular diastolic function, among whom 127 (127/190, 66.84%) had grade 1 left ventricular diastolic function, 55 (55/190, 28.95%) had grade 2 left ventricular diastolic function, and 8 (8/190, 4.21%) had grade 3 left ventricular diastolic function. There were significant differences between the observation group and the control group in IVRT (114.97±10.16 vs 72.86±8.75, P<0.05), Ea/Aa (0.79±0.11 vs 1.3±0.25, P<0.05), and A' value (5.21±1.03 vs 5.02±0.82, P<0.05). In the observation group, IVRT, Ea/Aa, and A' value for left ventricular diastolic dysfunction were correlated with the development of acute cerebral infarction (r=0.53, 0.61, and -0.59).Conclusions Left ventricular function dysfunction is associated with hypertension in young adults, and left ventricular diastolic dysfunction may be an independent predictive factor for acute cerebral infarction in young hypertensive patients.