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| 芪加合剂治疗实验性系膜增殖性肾炎的研究 | |
| 引用本文： | 钱玉润,龚学忠,周令芳,贾秀琴,郭竹英,胡春,徐芒华.芪加合剂治疗实验性系膜增殖性肾炎的研究[J].医学临床研究,2006,23(11):1712-1714. |
| 作者姓名： | 钱玉润 龚学忠 周令芳 贾秀琴 郭竹英 胡春 徐芒华 |
| 作者单位： | 1. 上海交通大学医学院第三人民医院肾内科,上海,201900 2. 上海市中医医院肾内科,上海,201901 3. 广东省深圳市第二人民医院中西医结合临床研究所,广东,深圳,518002 |
| 基金项目： | 上海交通大学校科研和教改项目 |
| 摘 要： | 【目的】探讨芪加合剂对新西兰大白鼠系膜增殖性肾小球肾炎（MesPGN）模型24h尿蛋白、肾功能及血脂的影响及其治疗MesPGN的机制。【方法】采用吴氏法建立兔的MesPGN模型，再通过灌服芪加合剂，观察MesPGN模型24h尿蛋白，肾功能，血脂以及肾脏形态学的变化。【结果】兔MesPGN模型24h尿蛋白定量较正常组明显增高，脂质代谢异常．肾组织病理改变明显。芪加舍剂能明显改善兔MesPGN模型的尿蛋白及脂代谢异常，减轻肾脏的病理损害。【结论】芪加合剂对系膜增殖性肾小球肾炎模型的治疗机制可能与纠正MesPGN模型脂代谢异常有关。 |
| 关 键 词： | 肾小球肾炎 膜增生性/药物疗法 |
| 文章编号： | 1671-7171(2006)11-1712-03 |
| 收稿时间： | 2006-09-08 |
| 修稿时间： | 2006年9月8日 |
Experimental Study of Qi Jia Mixture on Mesangial Proliferative Glomerulonephritis |
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| QIAN Yu- run, GONG Xue-zhong, ZHOU Ling-fang,et al.Experimental Study of Qi Jia Mixture on Mesangial Proliferative Glomerulonephritis[J].Journal of Clinical Research,2006,23(11):1712-1714. | |
| Authors: | QIAN Yu- run GONG Xue-zhong ZHOU Ling-fang |
| Abstract: | Objective]To explore the effect and mechanism of Qi Jia Mixture on rabbit model of mesangial proliferative glomerulonephritis (MesPGN) .Methods]Rabbit model of MesPGN was created according to Wu Heng Shengs article.Twenty four hours urinary protein, renal function and blood-lipid were observed after treatment of Qi Jia Mixture.Results]Twenty four hours urinary protein in the model was significantly increased as compared with control. Lipid-metabolism was abnormal. Qi Jia Mixture significantly improved rabbit model of MesPGN in urinary protein and abnormal lipid-metabolism. Conclusion]The mechanisms of Qi Jia Mixture in treating MesPGN may be related to correction of abnormal lipid-metabolism. |
| Keywords: | glomerulonephritis membranoproliferative |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
