早期肿块型乳腺浸润性导管癌超声征象与分子分型的相关性研究

目的 通过分析早期肿块型乳腺浸润性导管癌的超声征象与分子分型的相关性，探讨超声征象对早期肿块型乳腺浸润性导管癌分子分型的诊断价值。方法 纳入298例术前诊断为Ⅰ~Ⅱ期乳腺癌，且乳腺超声检查显示为肿块型病变，并经手术病理证实为乳腺浸润性导管癌的患者。比较此类乳腺癌不同分子分型的超声征象差异，Logistic回归分析Lum...

Correlation between ultrasonographic features and molecular subtypes of early mass-type breast invasive ductal carcinoma

Objective To investigate the diagnostic value of ultrasonic signs to molecular typing of early mass-type breast invasive ductal carcinoma by analyzing the correlation between ultrasonographic features and molecular types of early mass-type breast invasive ductal carcinoma. Methods A total of 298 patients with stage Ⅰ-Ⅱ breast cancer who were diagnosed by ultrasonography as mass-type lesions before operation and were confirmed as breast invasive ductal carcinoma by surgical pathology were retrospective included. The differences of ultrasonographic features and molecular subtypes were compared and analyzed. The influencing factors of Luminal type, HER-2 overexpression type and triple-negative type were analyzed by Logistic regression. Results Among 298 patients, 26 cases were Luminal A type, 178 cases were Luminal B type, 54 cases were HER-2 overexpression type and 40 cases were triple negative type. There were significant differences in age of onset, tumor diameter, margin, morphology, internal calcification and posterior echo between patients with different molecular types (P<0.05). There were no significant differences in axillary lymph node metastasis, growth direction, echo and blood flow signal (P>0.05). Irregular shape (OR=1.206, 95%CI: 1.039-1.400, P<0.05) and rough edge (OR=1.490, 95%CI: 1.224-1.814, P<0.05) were independent risk factors for Luminal type. The enhancement in posterior echo was the independent protective factor for Luminal type (OR=0.674, 95%CI: 0.603-0.752, P<0.05). Rough edge was the independent protective factor for HER-2 overexpression type (OR=0.688, 95%CI: 0.564-0.838, P<0.05). Irregular shape (OR=0.820, 95%CI: 0.728-0.923, P<0.05), attenuation in posterior echo (OR=0.714, 95%CI: 0.644-0.792, P<0.05), no change in posterior echo (OR=0.723, 95%CI: 0.662-0.791, P<0.05) and mixed echo in posterior echo (OR=0.790, 95%CI: 0.638-0.978, P<0.05) were independent protective factors for triple-negative type. Conclusion The ultrasonographic features can provide a basis for molecular typing of early mass-type breast invasive ductal carcinoma, which has certain clinical significance.