帕瑞昔布钠对60例鼾症手术患者围术期超前镇痛的疗效及安全性观察

目的观察帕瑞昔布钠用于鼾症手术患者围术期超前镇痛效果及安全性。方法行鼾症术患者60例,随机分为2组:帕瑞昔布钠组(A组)手术结束前30min给予帕瑞昔布钠40mg(10mL 0.9%氯化钠注射液稀释),对照组(B组)则给予10mL 0.9%氯化钠注射液。观察并记录给药前即刻,拔管时患者收缩压(SBP)、舒张压(DBP)和心率,计算最大变化率。拔管后1、3、6、18、24h进行视觉模拟评分(VAS)、躁动评分、Ramsay镇静评分,记录术后不良反应。结果拔管时帕瑞昔布钠组(A组)的SBP、DBP和心率比对照组(B组)低(P<0.05),且A组的最大变化率也低于B组(P<0.05)。帕瑞昔布钠组各时点VAS评分显著低于对照组(P<0.05),术后镇静评分则高于对照组(P<0.05)。A组的躁动率低于B组(P<0.05),而相应的恶心呕吐及头晕等不良反应的发生较对照组差异无统计学意义(P>0.05)。结论帕瑞昔布钠超前镇痛可以减轻鼾症手术术后疼痛、躁动,提高患者的舒适度,是一种安全可靠的镇痛方式。

Observation of efficacy and safety of preemptive analgesia with parecoxib sodium for sixty perioperative snoring patients

Objective To observe efficacy and safety of preemptive analgesia with parecoxib sodium for perioperative snoring patient.Methods Sixty surgical snoring patients were randomly divided into two groups: parecoxib sodium group(A) was given 40 mg parecoxib sodium(diluted with 10 mL normal saline) at 30 minutes before the end of surgery,and matched group was given 10 mL normal saline.To observe and record systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) after intubation,extubation,and to calculate the maximum rate of change.VAS score,agitation score,Ramsay sedation score at 1,3,6,18,24 h after extubation,and adverse reactions were recorded after surgry.Results SBP,DBP and HR in parecoxib sodium group(A) are lower than those in the matched group(B)(P<0.05) during extubation,and the maximum change rate in group A is less than that in the B group(P<0.05).VAS score of parecoxib sodium group at each time point was significantly lower than that in the matched group(P<0.05),postoperative sedation score is higher than that in the matched group(P<0.05).Agitation rate in group A is less than that in group B(P<0.05).There is no significant difference in adverse reactions such as nausea,vomiting and dizziness between group A and matched group(P>0.05).Conclusion Preemptive analgesia with parecoxib sodium is a safe and reliable analgesia pattern,which can reduce the postoperative pain and restlessness of surgical snoring patient,improve comfort index of patients.