| 钙结合蛋白S100A8在内毒素休克小鼠肝脏中的表达 |
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| 引用本文： | 李红梅,郑晶,黄劲. 钙结合蛋白S100A8在内毒素休克小鼠肝脏中的表达[J]. 现代预防医学, 2011, 38(15): 3085-3086,3088 |
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| 作者姓名： | 李红梅 郑晶 黄劲 |
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| 作者单位： | 1. 贵阳医学院生物化学与分子生物学教研室,贵阳,550004
2. 海南医学院病理学教研室 |
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| 摘 要： | [目的]探讨S100A8在内毒素休克小鼠肝脏组织中的表达。[方法]SPF级BALB/c小鼠随机分为正常对照组和LPS处理组(LPS刺激1h、3h和6h,LPS剂量为35mg/kg);采用免疫组织化学染色法检测两组肝脏组织S100A8蛋白水平的变化。[结果]S100A8在内毒素休克小鼠肝组织的胞浆及胞膜上表达增强。[结论]S100A8在内毒素休克的肝组织中表达增强,提示S100A8可能参与LPS诱导的信号转导。
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| 关 键 词： | 内毒素休克 S100A8 炎症反应 |
EXPRESSION OF CALCIUM-BINDING PROTEIN S100A8 IN ENDOTOXIC SHOCK |
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| LI Hong-mei,ZHENG Jing,HUANG Jing. EXPRESSION OF CALCIUM-BINDING PROTEIN S100A8 IN ENDOTOXIC SHOCK[J]. Modern Preventive Medicine, 2011, 38(15): 3085-3086,3088 |
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| Authors: | LI Hong-mei ZHENG Jing HUANG Jing |
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| Affiliation: | LI Hong-mei,ZHENG Jing,HUANG Jing.(Department of Biochemistry and Molecular Biology of Guiyang Medical College,Guiyang 550004,China) |
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| Abstract: | [Objective]To investigate the expression of S100A8 in endotoxic shock.[Methods]BALB/c mice were assigned to 2 groups:the control group and LPS-treated group(1h,3h and 6h after peritoneal injection of LPS). The protein expression of S100A8 was tested through immunohistochemistry.[Results]It showed that the protein expression of S100A8 was increased in the plasma and plasma membrane of liver cells.[Conclusion]The expression of S100A8 is increased in liver of endotoxic shock,it suggests that S100A8 probably pa... |
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| Keywords: | Endotoxic shock S100A8 Inflammatory response |
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