| 人与不同种属动物骨髓粒系祖细胞对硫芥敏感性的比较 |
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| 引用本文： | 李凤仙,冯杏婉.人与不同种属动物骨髓粒系祖细胞对硫芥敏感性的比较[J].中国药理学与毒理学杂志,1989,3(2):149-153. |
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| 作者姓名： | 李凤仙 冯杏婉 |
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| 作者单位： | 军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所 北京 100850，北京 100850，北京 100850 |
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| 摘 要： | 本文用半固体琼脂体外培养技术和琼脂扩散盒体内培养技术测定了人和不同种属动物骨髓粒系祖细胞(CFU—GM),比较了在体内与体外条件下硫芥对不同种属动物骨髓CFU—GM的剂量存活曲线。人、犬、大鼠和小鼠离体骨髓细胞受硫芥作用后CFU—GM的剂量存活曲线在半对数座标图中呈指数性直线,D_(10)(μmol/L)分别为:人0.79,犬0.24,大鼠0.49,小鼠0.84,对硫芥的敏感性以犬最敏感.其次是大鼠.人和小鼠相对最低.硫芥中毒犬、大鼠和小鼠骨髓CFU—GM对硫芥敏感性与体外结果基本一致.
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| 关 键 词： | 粒系祖细胞 硫芥 剂量存活曲线 |
The comparison of sensitivity of bone marrow CFU-GM from human and various species to sulfur mustard |
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| LI Feng-xian,FENG Xing-wan,CHENG Jun-ping.The comparison of sensitivity of bone marrow CFU-GM from human and various species to sulfur mustard[J].Chinese Journal of Pharmacology and Toxicology,1989,3(2):149-153. |
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| Authors: | LI Feng-xian FENG Xing-wan CHENG Jun-ping |
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| Abstract: | Using a semi-solid agar colony-forming assay in vitro and cultured diffusion chamber assay in vivo the sensitivity of bone marrow CPU-GM from various species human,dog,rat and mouse to sulfur mustard was determined.Dose-survival curves of bone marrow CPU-GM exposed to sulfur mustardin vivo or in vitro are single exponential types.The sensitivity of CFU-GM from various species to sulfur mustard either ivivo or in vitro is in the order dog>rat>human and mouse. |
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| Keywords: | CFU-GM sulfur mustard dose-survival curves |
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