| 二氟泼尼酯的合成 |
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| 引用本文： | 孔祥雨,刘宪华,赵思太,任业明,姜明俊.二氟泼尼酯的合成[J].齐鲁药事,2013(12):739-739,741. |
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| 作者姓名： | 孔祥雨 刘宪华 赵思太 任业明 姜明俊 |
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| 作者单位： | 山东省化药重点实验室山东省医药工业研究所,山东济南250101 |
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| 摘 要： | 目的合成二氟泼尼酯。方法以6α,9α-二氟泼尼龙为起始原料,经酯化、水解、乙酰化得到二氟泼尼酯。结果合成了二氟泼尼酯。结论目标化合物结构经MS、1H-NMR确证,该反应路线操作简洁,总收率为67.1%。
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| 关 键 词： | 二氟泼尼酯 合成 工艺改进 |
Synthesis of difluprednate |
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| KONG Xiang-yu,LIU Xian-hua,ZHAO Si-tai,REN Ye-ming,JIANG Ming-jun.Synthesis of difluprednate[J].qilu pharmaceutical affairs,2013(12):739-739,741. |
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| Authors: | KONG Xiang-yu LIU Xian-hua ZHAO Si-tai REN Ye-ming JIANG Ming-jun |
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| Affiliation: | (Key Laboratory for Chemical Drug Research of Shandong Province, Shandong Institute of Pharmaceutical Industry, Jinan 250101, China ) |
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| Abstract: | Objective To synthesis Difluprednate. Methods Difluprednate was synthesized from the materials 6α,9α - difluoroprednisolone and methyl orthobutyrate by orthoesterifieation, hydrolysis and esterifieation. Results Difluprednate was synthesized. Conclusion The structure of the target compound was characterized by MS and 1H - NMR. The synthetic procedure was convenient and the total yield of the target compound was 67. 1%. |
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| Keywords: | Difluprednate Synthesis Technology improvement |
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