急性颅脑损伤患者凝血-纤溶功能与颅内出血及预后的相关性

目的：研究急性颅脑损伤患者早期凝血-纤溶功能变化与颅内出血和预后的关系。方法：检测196例急性颅脑损伤患者24h内的格拉斯哥昏迷评分（GCS）、凝血酶原时间（PT）、凝血酶时间（TT）、部分活化凝血酶原时间（APTT）、D-二聚体浓度（D-D）,作2次或多次CT扫描,分析颅脑损伤患者急性期凝血-纤溶功能的变化与颅内出血和预后的关系。结果：196例颅脑损伤患者的早期D-二聚体浓度变化以颅内血肿患者最为明显,并与颅脑损伤严重程度和预后密切相关。结论：颅脑损伤早期存在凝血-纤溶功能变化,颅脑损伤者早期应密切检查凝血-纤溶功能,如有异常应及时行动态头颅CT检查以及早发现迟发性颅内血肿,提高临床救治水平。

Correlation between Coagulation-Fibrinolysis and Progressive Intracranial Hemorrhage and Prognosis in Patients with Acute Traumatic Brain Injury

Objective：Study the relationship between early change of coagulation-fibrinolysis function and prognosis in acute brain traumatic patients.Methods： The GCS,prothrombin time（PT）,thrombin time（TT）,activated partial thromboplastine time（APTT）,D-dimer（D-D） and CT in 196 acute brain traumatic patients were measured.The relationship between the change of coagutation-fibridysis function and the prevanlence of intracranial hematoma was analyzed.Results： The D-D change was most significant in brain hematoma patients and was closely related to the prognosis.Conclusions： The coagulation-fibrirolysis function changed early in brain traumatic patients and shonld be detected closely.CT scan can detect delayed intracranial hematoma.