化疗对肠道菌群及血清5-羟色胺水平的影响

化疗不仅导致肠黏膜炎和5-羟色胺（5-HT）水平的异常，也会诱发肠道菌群失衡。平衡状态下的微生物是一道生物屏障，菌群失衡可加剧肠道炎症。近期研究发现，5-HT的水平受肠道菌群的调节。因此，化疗引起的5-HT水平改变可能与肠道菌群的异常有关。本研究主要探讨肠道菌群通过何种途径影响化疗后肠黏膜炎和5-HT水平，为临床上以益生菌调节肠道菌群来改善化疗后的胃肠道反应提供依据。

Effect of chemotherapy on intestinal microbiota and serum 5-HT level

Chemotherapy induces not only intestinal mucisitis and abnormal 5-HT level, but also dysbiosis of intestinal microbiota. Intestinal microbiota in a state of equilibrium act as a biological barrier, while the imbalance of gut microbiota can exacerbate gut mucosal inflammation. Recent research found that the level of 5-HT is regulated by the gut microbiota. Therefore, abnormal level of 5-HT may be related to the the changes of gut microbiota caused by chemotherapy. This paper mainly discusses the ways in which gut bacteria affect chemotherapy induced mucositis and 5-HT level, in order to provide theoretical basis for the regulation of gut microbiota and remissioin of chemotherapy induced gastrointestinal reactions with probiotics.