| 他克莫司-聚三亚甲基碳酸酯药物洗脱支架涂层研究 |
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| 引用本文： | 吴雷刚,吴婧,侯瑞霞,王进,黄楠.他克莫司-聚三亚甲基碳酸酯药物洗脱支架涂层研究[J].功能材料,2011,42(11). |
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| 作者姓名： | 吴雷刚 吴婧 侯瑞霞 王进 黄楠 |
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| 作者单位： | 西南交通大学材料学院,材料先进技术教育部重点实验室,四川成都610031 |
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| 基金项目： | 国家自然科学基金资助项目(50971107); 教育部新世纪优秀人才支持计划资助项目(NCET-07-0715) |
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| 摘 要： | 以表面溶蚀性可降解聚合物聚三亚甲基碳酸酯（PTMC）为载体,分别采用超声雾化喷涂技术和溶液浇注法制备了以PTMC为涂层载体的他克莫司药物洗脱支架和载药薄膜。傅里叶红外光谱（FT-IR）结果显示他克莫司分散在PTMC中。扫描电子显微镜观察支架撑开后的药物涂层保持连续均匀,没有开裂和剥落。他克莫司洗脱支架的药物释放行为与Weibull模型的相关性最高。体外血小板粘附和平滑肌粘附、增殖实验表明包载他克莫司的PTMC表面具有显著地抑制血小板粘附和平滑肌增生的作用。
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| 关 键 词： | 药物洗脱支架 聚三亚甲基碳酸酯 他克莫司 药物释放 平滑肌增生 |
Study on tacrolimus-loaded poly(1,3-trimethylene carbonate) as drug-eluting stent coating |
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| WU Lei-gang,WU Jing,HOU Rui-xia,WANG Jin,HUANG Nan.Study on tacrolimus-loaded poly(1,3-trimethylene carbonate) as drug-eluting stent coating[J].Journal of Functional Materials,2011,42(11). |
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| Authors: | WU Lei-gang WU Jing HOU Rui-xia WANG Jin HUANG Nan |
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| Affiliation: | WU Lei-gang,WU Jing,HOU Rui-xia,WANG Jin,HUANG Nan(Key Laboratory of Advanced Technology for Materials of Education Ministry,Southwest Jiaotong University,Chengdu 610031,China) |
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| Abstract: | One kind of tacrolimus eluting stent coated with biodegradable poly(1,3-trimethylene carbonate)(PTMC) was developed.The results of Fourier transform infrared spectroscopy(FT-IR) and X-ray diffraction(XRD) analysis proved the chemical stability of tacrolimus loaded in PTMC matrix.Stent coating were examined by scanning electron microscopy(SEM),indicating that the coating not only was very smooth and uniform but also had the ability to withstand the compressive and tensile strains.In vitro drug release of tac... |
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| Keywords: | drug-eluting stent poly(1 3-trimethylene carbonate) tacrolimus drug controlled release platelets adhesion smooth muscle cells proliferation |
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