Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms |
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Authors: | Rutgers Abraham Heeringa Peter Giesen Joyce E H M Theunissen Ruud T Jacobs Heinz Tervaert Jan Willem Cohen |
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Affiliation: | Clinical and Experimental Immunology, University Hospital Maastricht, Maastricht, The Netherlands. b.rutgers@immuno.unimaas.nl |
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Abstract: | Myeloperoxidase (MPO) catalyses the formation of hypochlorous acid and is involved in many (patho)physiological processes. The present study was designed to determine the effect of two MPO promoter polymorphisms (463G/A and 129G/A) on enzyme activity. In 243 healthy controls, genotypes were determined and MPO activity was measured on a single-cell level using a haematological analyser. The 129G/A polymorphism reduces MPO activity in neutrophils, whereas for the 463G/A polymorphism, only gender-dependent differences in MPO activity in older age groups could be found. When studying these polymorphisms in disease, therefore, age and gender should be included in the analysis. |
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Keywords: | myeloperoxidase hypochlorous acid peroxidase gender oestrogen |
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