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Live birth after blastocyst transfer following only 2 days of progesterone administration in an agonadal oocyte recipient
Authors:Efstathios Theodorou  Robert Forman
Affiliation:1. Orlando Immunology Center, Orlando, FL, USA;2. Midway Immunology and Research Center, Fort Pierce, FL, USA;3. The Crofoot Research Center, Houston, TX, USA;4. Ruane Medical, Los Angeles, CA, USA;5. Therafirst Medical Center, Fort Lauderdale, FL, USA;6. Southern California Men''s Medical Group, Los Angeles, CA, USA;7. The Research Institute, Springfield, MA, USA;8. Spectrum Health Care, Vancouver, BC, Canada;9. ICH Study Center, Hamburg, Denmark;10. Hopital Saint Louis, Paris, France;11. Kings College Hospital, London, UK;12. Hospital Universitario La Paz, Madrid, Spain;13. Gilead Sciences, Foster City, CA, USA;1. The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050011, PR China;2. Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA;3. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA;1. Department of Animal Science, United States;2. Center for Animal Biotechnology and Genomics, Texas A&M University, College Station, TX 77843, United States;3. Department of Theriogenology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt;4. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt;1. Division of Nephrology, Department of Medicine, McMaster University, Canada;2. Research Institute of St. Joe''s Hamilton, Canada;3. The Hamilton Center for Kidney Research, St. Joseph''s Hospital, Hamilton, Ontario, Canada;4. Department of Pathology and Molecular Medicine, Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON, Canada;1. Department of Obstetrics and Gynaecology, Division of Obstetrics & Prenatal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands;2. Department of Public Health, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands;3. Institute of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands;4. Rotterdam Midwifery Academy, ‘Rochussenstraat building’, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Abstract:In oocyte donation cycles where hormone replacement is given to recipients, progesterone administration is necessary to induce the luteal phase and synchronize the endometrium with the embryo stage. Most studies suggest that 5–7 days of progesterone are needed to prepare the endometrium for a day-5 embryo transfer and provide optimal implantation rate. This paper reports a case where an agonadal oocyte recipient received only 2 days of progesterone prior to the embryo transfer of a day-5 embryo. She subsequently had a clinical pregnancy and a live birth.
Keywords:
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