| 大鼠再生肝的抗四氯化碳损伤作用与金属硫蛋白 |
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| 引用本文： | 张宝弘,王玲,程时,张席锦. 大鼠再生肝的抗四氯化碳损伤作用与金属硫蛋白[J]. 北京大学学报(医学版), 1990, 0(6) |
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| 作者姓名： | 张宝弘 王玲 程时 张席锦 |
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| 作者单位： | 大连医学院生理教研室(张宝弘)，北京医科大学生理学教研室(王玲)，北京医科大学生物物理教研室(程时)，北京医科大学生理学教研室(张席锦) |
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| 摘 要： | 金属硫蛋白(Metallothionein,MT)是富含半胱氨酸和金属的非酶蛋白,具有清除自由基的作用,主要在肝脏合成。本工作探讨了再生肝抗四氯化碳(CCl_4)损伤作用与其MT含量的关系。以血清胆红素浓度和谷丙转氨酶(sGPT)活性为指标,观察了CCl_4对肝部分切除后2、4、6、8天大鼠再生肝的损伤情况,并对应地测定了肝脏MT含量。结果表明,二者的变化密切相关,肝部分切除后4天再生肝对CCl_4的抗损伤作用最为明显,同时MT含量的增加适达高峰。
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| 关 键 词： | 再生肝 四氯化碳 肝保护 金属硫蛋白 |
PROTECTION OF REGENERATING LIVER AGAINST CARBON TETRACHLORIDE IN RATS AND METALLOTHIONEIN |
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| Zhang Baohong,et al. PROTECTION OF REGENERATING LIVER AGAINST CARBON TETRACHLORIDE IN RATS AND METALLOTHIONEIN[J]. Journal of Peking University. Health sciences, 1990, 0(6) |
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| Authors: | Zhang Baohong et al |
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| Affiliation: | Zhang Baohong,et al Department of Physiology |
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| Abstract: | Metallothionein (MT) is a non-enzyme protein rich in cystein and metals, one of its functionsis of cleaning away free-radicals. MT is mainly synthesized in the liver. In this experiment, relationshipbetween protection of regenerating liver against carbon tetrachloride (CCl_4) injury and its MT contentwas studied. CCl_4 induced injury as indicated by serum bilirubin concentration and sGPT activity wasobserved in rats at 2, 4, 6, 8days following partial hepatectomy, and hepatic MT content was determi-ned correspondingly. The results showed that there is a closely correlative relationship betweeen them.The regencrating liver of the rats 4 days after partial hepatectomy showed an obvious protection againstCCl_4, and at the same time, the increase in MT content just reached at the top. |
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| Keywords: | Regenerating liver Carbon tetrachloride Hepatic protection Metallothionein |
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