超声造影评价氩氦刀消融治疗肝脏恶性肿瘤的疗效

目的探讨超声造影（CEUS）评价氩氦刀消融治疗肝癌局部疗效的意义。方法超声引导下对27例肝癌患者的27个病灶行氩氦刀消融治疗术,用CEUS评价其局部疗效;并以同期增强CT（CECT）作为对比。结果术后1个月复查CEUS示病灶完全消融21个（77.78%）,不完全消融为6个（22.22%）;CECT提示病灶完全消融为22个（81.48%）,不完全消融5个（18.52%）。同CECT比较,CEUS的诊断敏感性、特异性、阳性预测值、阴性预测值、准确性分别为80.00%（4/5）、90.91%（20/22）、66.67%（4/6）、95.24%（20/21）和88.89%（24/27）。结论CEUS可作为评价氩氦刀消融治疗肝癌局部疗效的一种有效手段。

Contrast-enhanced ultrasound evaluation of efficacy of argon-helium cryoablation in the treatment of liver malignancies

Objective To observe the value of contrast-enhanced ultrasound (CEUS) in the evaluation of efficacy of Argon-Helium cryoablation therapy for liver malignancies. Methods A total of 27 patients with 27 lesions of liver malignancies underwent ultrasound-guided Argon-Helium cryoablation therapy. CEUS was used to evaluate the local response and compared with contrast-enhanced CT (CECT). Results One month after Argon-Helium cryoablation therapy, 21 lesions (77.78%) were diagnosed as complete ablation with CEUS and 22 (81.48%) with CECT. Contrast enhancement within lesions was demonstrated in 6 lesions (22.22%) with CEUS and 5 (18.52%) with CECT. As compared to CECT, the sensitivity, specificity, positive and negative predictive value, and accuracy of CEUS in diagnosing tumor residue 1 month after treatment was 80.00% (4/5), 90.91% (20/22), 66.67% (4/6), 95.24% (20/21), and 88.89% (24/27),respectively. Conclusion CEUS is an effective alternative for the evaluation of efficacy of Argon-Helium cryoablation in the treatment of liver malignancies.