BNP在糖尿病肾病患者血浆中的变化

目的]研究糖尿病肾病（diabetic nephropathy,DN）患者血浆脑利钠肽（BNP）水平及其与糖尿病肾病的关系。方法]随机选择2型糖尿病患者106例,按尿微量白蛋白排泄率（UAER）分为大量蛋白尿组（UAER〉200μg/min36例）,微量白蛋白尿组（UAER 20-200μg/min 38例）,非白蛋白尿组（UAER〈20μg/min 32例）,健康成人30例作为对照组。应用电化学发光法测定各组BNP水平。结果]微量白蛋白尿组、大量白蛋白尿组血浆BNP水平明显高于非白蛋白尿组（分别为（192.1±72.5）pg/mL、（429.9±165/3）pg/mL、（101.3±46.7）pg/mL,P〈0.01）,后者高于正常对照组,（57.6±43.4）pg/mL,P〈0.01,且与UAER呈明显正相关（r=0.83.P〈0.01）。结论]糖尿病肾病患者血浆BNP水平明显升高,可能在糖尿病肾病发生、发展过程中发挥重要作用。

Clinical application of plasma BNP detection in diabetic nephropathy patients

Objective] To investigate the relationship between plasma brain natriuretic peptide level in diabetic patients and diabetic nephropathy, and to evaluate its clinical significance simutanously. Methods ] One hundred and six patients with type 2 diabetic mellitus were enrolled at random. According to urinary albumin execration rate （ UAER）, 106 patients were divided into three groups ： macroalbuminuric group （ UAER 〉 200 μg/min）, microalbuminuric group （ 20 μg/min 〈 UAER 〈 200 txg/min） and nonalbuminuric group（ UAER 〈20 μg/min）. The plasma levels of BNP were measured with electrochemiluminescence immunoassay （ ECLIA ）. Result ] The plasma BNP levels of macroalbuminuric group and microalbuminuric group were significantly higher than those of nonalbuminuric group （ 192.1±72.5 ） pg/mL, （429.9± 165.3 ） pg/mL, （ 101.3 ±46.7） pg/mL,P 〈0.01. The blood BNP concentration of nonalbuminuric group increase significantly compared with control group （ 101.3±46.7 ） pg/mL, （57.6±43.4 ） pg/mL, P 〈 0.01. The plasma levels of BNP were positively and significantly correlated with UAER in diabetic nephropathy. Conclusion] The plasma levels of BNP were significantly increased in patients with diabetic nephropathy, which probably play an important role in the ocurrence and development of this disease.