| CD20阳性成人急性B淋巴细胞白血病患者临床特点及生存分析 |
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| 引用本文： | 马杰,孙慧,陈胜梅,刘林湘,陈绍倩,刘延方,谢新生,孟小莉,邓梅,张秋堂,李涛. CD20阳性成人急性B淋巴细胞白血病患者临床特点及生存分析[J]. 中国实验血液学杂志, 2010, 18(2): 477-481 |
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| 作者姓名： | 马杰 孙慧 陈胜梅 刘林湘 陈绍倩 刘延方 谢新生 孟小莉 邓梅 张秋堂 李涛 |
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| 作者单位： | 郑州大学第一附属医院血液内科,河南郑州,450052;河南省高等学校临床医学重点学科开放实验室,河南郑州,450052 |
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| 摘 要： | 本研究分析成人CD20阳性急性B淋巴细胞白血病(B-lineage acute lymphoblastic leukemia,B-ALL)患者的临床特点和生存情况。回顾性总结分析郑州大学第一附属医院血液科2004年5月至2008年12月收治的119例成人B-ALL患者的临床特点和生存情况。结果表明:119例成人B-ALL中CD20阳性40例(33.61%),CD20阴性者79例(66.39%),CD20阳性组和CD20阴性组男性患者比例分别为72.50%和50.63%(p0.05),CD20阳性组和CD20阴性组发病时外周血白细胞数分别为(27.35±30.29)×109/L和(50.11±81.72)×109/L(p0.05)。两组患者在年龄分布、肝脾、淋巴结和中枢神经系统浸润、发病时血红蛋白和血小板水平、髓系抗原表达、Ph染色体、超二倍体和正常核型比例、4周内完全缓解率、诱导死亡率和复发率方面的差异无统计学意义(p0.05);Kaplan-Meier曲线生存率分析显示,CD20阳性组和CD20阴性组成人B-Lin ALL的中位总体生存(OS)时间分别为11.0个月和12.0个月,3年总生存率分别为28%和20%,两组间差异无统计学意义(p=0.832)。结论:CD20在成人B-ALL中的表达与患者的性别分布、外周血白细胞数相关,与其它临床特点无显著相关性,对患者的预后无显著影响。
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| 关 键 词： | CD20 急性B淋巴细胞白血病 临床特点 生存分析 |
Clinical Features and Survival Analysis of Patients with CD20 Positive Adult B-lineage Acute Lymphoblastic Leukemia |
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| MA Jie,SUN Hui,CHEN Sheng-Mei,LIU Lin-Xiang,CHEN Shao-Qian,LIU Yan-Fang,XIE Xin-Sheng,MENG Xiao-Li,DENG Mei,ZHANG Qiu-Tang,LI Tao. Clinical Features and Survival Analysis of Patients with CD20 Positive Adult B-lineage Acute Lymphoblastic Leukemia[J]. Journal of experimental hematology, 2010, 18(2): 477-481 |
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| Authors: | MA Jie SUN Hui CHEN Sheng-Mei LIU Lin-Xiang CHEN Shao-Qian LIU Yan-Fang XIE Xin-Sheng MENG Xiao-Li DENG Mei ZHANG Qiu-Tang LI Tao |
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| Affiliation: | MA Jie,SUN Hui,CHEN Sheng-Mei,LIU Lin-Xiang,CHEN Shao-Qian,LIU Yan-Fang,XIE Xin-Sheng,MENG Xiao-Li,DENG Mei,ZHANG Qiu-Tang,LI Tao Department of Hematology,The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan Province,China,Open Laboratory of Clinical Medical Key Disciplines of Henan Provincial High Institution |
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| Abstract: | The aim of this study was to explore the clinical features and survival of adult patients with CD20 positive B-lineage acute lymphoblastic leukemia(B-ALL).The clinical manifestations,examination results,therapeutic effect and survival rate of 119 adult B-ALL patients diagnosed and treated in our hospitcl from May 2004 to Jannary 2008 were analyzed retrospectively.The results showed that among 119 cases,CD20 positive B-ALL accounted for 40 cases(33.61%),CD20 negative B-ALL patents accounted for 79 cases(66.3... |
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| Keywords: | CD20 B-lineage acute lymphoblastic leukemia clinical features survival analysis |
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