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Towards functional spin-echo BOLD line-scanning in humans at 7T |
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| Authors: | Raimondo Luisa Heij Jurjen Knapen Tomas Dumoulin Serge O. van der Zwaag Wietske Siero Jeroen C. W. |
| Affiliation: | 1.Spinoza Centre for Neuroimaging, Meibergdreef 75, 1105 BK, Amsterdam, The Netherlands ;2.Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands ;3.Experimental and Applied Psychology, VU University, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands ;4.Experimental Psychology, Utrecht University, PO Box 80125, 3508 TC, Utrecht, The Netherlands ;5.Radiology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands ; |
| Abstract: | Objective Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In this work, we implemented a spin-echo line-scanning (SELINE) sequence to use in high spatial and temporal resolution fMRI. Materials and methodsA line is formed by simply rotating the spin-echo refocusing gradient to a plane perpendicular to the excited slice and by removing the phase-encoding gradient. This technique promises a combination of high spatial and temporal resolution (250 μm, 500 ms) and microvascular specificity of functional responses. We compared SELINE data to a corresponding gradient-echo version (GELINE). ResultsWe demonstrate that SELINE showed much-improved line selection (i.e. a sharper line profile) compared to GELINE, albeit at the cost of a significant drop in functional sensitivity. DiscussionThis low functional sensitivity needs to be addressed before SELINE can be applied for neuroscientific purposes. |
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