HDAC7在肾癌组织中的表达及其临床意义

目的检测并分析肾癌(透明细胞癌)组织中HDAC7mRNA和蛋白的表达差异,探讨其与肾癌的发生、发展以及患者预后之间的关系。方法应用实时荧光定量PCR和免疫组化法对60例肾癌组织及20例正常肾组织中HDAC7的表达情况进行检测,并通过对患者随访,探讨其蛋白表达水平与肾癌临床病理学指标及患者预后之间的关系。结果HDAC7在肾癌组织中的表达较正常肾组织明显增高,且与肾癌的病理分级和临床分期之间均呈负相关(P<0.05)。HDAC7低表达者的生存率低于HDAC7高表达者(P<0.05)。结论 HDAC7可能与肾癌的发生、发展有关,提示HDAC7可作为评估肾癌恶性程度及预后的肿瘤标志物。

Expression of HDAC7 in renal cell carcinoma and its clinical significance

Objective To investigate the mRNA and protein expression of HDAC7 in renal cell carcinoma,and to study the clinical value of protein level in the occurrence,progression of renal cell carcinoma(RCC).Methods 60 cases RCC and 20 normal renal tissue specimens had been detected by real time fluorescence quantitative PCR and immunohistochemical methods.Then we analyzed the relationship between HDAC7 protein level and clinical parameters as well as the prognosis of patients.Results The expression of HDAC7 was higher in RCC than that in normal renal tissue.There were significantly positive correlation between the expression of HDAC7 protein and the pathological grades/stages of rRCC(P< 0.05).The survival rate of these patients whose low expression of HDAC7 protein was lower than those of high expression of HDAC7 protein.Conclusion There may be relationship between the expression of HDAC7 protein and the occurrence,progression of RCC.HDAC7 can be used as a tumor marker for the evaluation of malignant potential and prognosis of RCC.