| 免疫促进剂匹多莫德的合成改进 |
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| 引用本文： | 李秀珍,王赟,商志才,俞庆森.免疫促进剂匹多莫德的合成改进[J].化学世界,2005,46(9):555-557. |
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| 作者姓名： | 李秀珍 王赟 商志才 俞庆森 |
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| 作者单位： | 浙江大学化学系,浙江,杭州,310027 |
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| 摘 要： | 以L-半胱氨酸、L-焦谷氨酸为起始原料,经三步合成了匹多莫德.在传统的合成方法基础上进行了一定的改进,即在第二步的酯化反应中采用了冰浴条件下向无水甲醇中滴加CH3COCl,得到甲醇的HCl溶液,在其未达到饱和状态时仍取得了比较好的酯化结果,提高了产率,适合工业化.
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| 关 键 词： | 免疫促进剂 匹多莫德 L-半胱氨酸 L-焦谷氨酸 |
| 文章编号： | 0367-6358（2005）09-555-03 |
| 收稿时间： | 2004-07-26 |
| 修稿时间： | 2004-07-262004-08-25 |
An Improvement on the Synthesis of Pidotimod |
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| LI Xiu-zhen,WANG Yun,SHANG Zhi-cai,YU Qing-sen.An Improvement on the Synthesis of Pidotimod[J].Chemical World,2005,46(9):555-557. |
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| Authors: | LI Xiu-zhen WANG Yun SHANG Zhi-cai YU Qing-sen |
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| Abstract: | Pidotimod, ara immunomodulator was synthesized in a three-step process with L-cysteine and L-pyroglutamic acid as starting materials. In this method, acetyl chloride was added to absolute methanol drop wise at the ice-bath temperature and an unsaturated solution of hydrogen chloride in methanol was obtained in the second step. This method gives good yield and is well adapted to industrialization |
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| Keywords: | immunomodulator pidotimod L-cysteine L-pyroglutamic acid |
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