佛甲草抗炎作用研究

目的:研究佛甲草(Sedum lineare Thunb,SLT)的抗炎作用。方法:采用二甲苯致小鼠耳廓肿胀、醋酸致小鼠腹腔毛细血管通透性增加、植入棉球致小鼠肉芽组织增生等炎症模型,观察SLT的抗炎作用;测定小鼠胸腺、脾脏指数,观察SLT对免疫器官质量的影响。结果:SLT可明显抑制二甲苯致小鼠耳廓肿胀、醋酸致小鼠腹腔毛细血管通透性增加,能显著抑制小鼠肉芽组织增生,降低胸腺指数,升高脾指数。结论:SLT有明显的抗炎作用,其抗炎机制与调节免疫功能有关。

Anti-inflammatory Effect of Sedum lineare in Mice

Objective: To investigate the anti-inflammatory effect of Sedum lineare Thunb(SLT). Method: Three models were used to explore the anti-inflammatory effect of SLT. Two acute inflammatory models were made in mice, one was ear edema induced by d imethylbenzene, and the other was higher permeability of blood capillary induced by acetic acid. The chronic inflammatory model of granulation tissue was established by cotton pellets implantation in mice. Result: SLT suppressed the swelling of earflaps induced by dimethylbenzene, decreased the permeability of blood capillary induced by acetic acid obviously, and it significantly inhibited the proliferation of granulation tissue. SLT also decreased thoracic gland index and enhanced the spleen index in chronic inflammatory model. Conclusion: The SLT has obvious anti-inflammatory effect, which may result from modulating immune function.