| 银杏叶提取物对Aβ诱导神经毒性的保护作用 |
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| 引用本文： | 张华军,万茜,徐天舒. 银杏叶提取物对Aβ诱导神经毒性的保护作用[J]. 中国实验方剂学杂志, 2011, 17(2): 209-212 |
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| 作者姓名： | 张华军 万茜 徐天舒 |
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| 作者单位： | 南京大学医学院附属鼓楼医院中西医结合科,南京,210008 |
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| 摘 要： | 目的:研究不同剂量银杏叶(ginkgo biloba extract,EGb761)对Aβ诱导神经元损伤的影响。方法:取高、中、低剂量的EGb761质量浓度分别为100,10,1 mg·L-1预处理Aβ1-42干预的神经元,检测神经元活力、凋亡率及NeuN染色的变化。结果:与Aβ组相比,高和低剂量EGb761组的神经元活力和NeuN+细胞数存在显著差异(P<0.05),而中剂量EGb761组神经元活力和NeuN+细胞数均存在极显著差异(P<0.01);中剂量EGb761组的对神经元凋亡的保护作用优于高、低剂量EGb761组。结论:高、中、低剂量组银杏叶制剂均可提高损伤海马神经元活力、提高NeuN+细胞数,降低神经元凋亡率;尤以中剂量组显著。提示采用预处理的给药方式可保护Aβ诱导的神经元损伤。
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| 关 键 词： | 银杏叶提取物 Aβ诱导神经毒性 神经保护 |
| 收稿时间： | 2010-09-01 |
Neuroprotective Effects of Ginkgo biloba Extract Against Beta-amyloid Peptide-induced Toxicity in Hippocamal Neurons |
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| ZHANG Hua-jun,WAN Qian and XU Tian-shu. Neuroprotective Effects of Ginkgo biloba Extract Against Beta-amyloid Peptide-induced Toxicity in Hippocamal Neurons[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(2): 209-212 |
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| Authors: | ZHANG Hua-jun WAN Qian XU Tian-shu |
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| Affiliation: | Department of Integrated Traditional Chinese and Western Medicine,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Integrated Traditional Chinese and Western Medicine,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Integrated Traditional Chinese and Western Medicine,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China |
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