赖诺普利对Ⅱ型糖尿病合并高血压患者胰岛素敏感性的影响

目的　探讨赖诺普利对Ⅱ型糖尿病合并高血压患者胰岛素敏感性的影响。方法　 31例Ⅱ型糖尿病合并高血压患者 ,每日口服赖诺普利 ,于服药前及服药后 8周末分别检测血压 (BP)、空腹血糖 (FBG)和空腹血浆胰岛素 (INS)、并作口服葡萄糖耐量试验 ,同时测定血浆胰岛素。结果　赖诺普利治疗后血压及血糖水平均明显降低 (P <0 .0 1) ,胰岛素敏感指数增高 (P <0 .0 1)。结论　赖诺普利可降低Ⅱ型糖尿病合并高血压患者血压及血糖水平 ,显著提高胰岛素敏感性。

Effects of Lisinopril on Insulin Sensitivity in Patients with Type-2 diabetes Complicated Hypertensive

Objective To study the effects of lisinopril on insulin sensitivity in patients with type-2 diabetes complicated hypertensive. Methods 31 type-2 diabetes complicated hypertensive were treated with lisinopril, we examined the levels of blood pressure and plasma glucose and insulin in a fasting state at baseline and at the ends of 8 weeks of therapeutic, The oral glucose tolerancectest(OGTT)was performed, insulin was examined at the same time. Results After treatment, blood pressure and plasma glucose were significantly reduced( P <0.01), insulin sensitivity indexes was increased significantly( P <0.01). Conclusion Lisinopril may significantly reduce the levels of blood pressure and plasma glucose and increase insulin sensitivity in patients with type-2 diabetes complicated hypertensive.