| 心律泰对离体豚鼠乳头肌动作电位的影响 |
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| 引用本文： | 黄璞,王国斌,刘力强,徐白鹭. 心律泰对离体豚鼠乳头肌动作电位的影响[J]. 中国药师, 2006, 9(6): 488-490 |
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| 作者姓名： | 黄璞 王国斌 刘力强 徐白鹭 |
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| 作者单位： | 1. 华中科技大学同济医学院附属协和医院药剂科,武汉,430022
2. 华中科技大学同济医学院药理系 |
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| 摘 要： | 目的:研究心律泰对离体豚鼠乳头肌动作电位的影响。方法:采用标准微电极细胞内记录技术。结果:心律泰呈浓度依赖性地降低离体豚鼠乳头肌动作电位(AP)的Vmax、APA,缩短APD20、APD50、APD90。中浓度时(4 mg生药／ml),使Vmax, APA,APD20,APD50,APD90由给药前的122．6±25．4 v／s,98．0±10．8 mv,114．4±16．7 ms,174．7±25．0 ms,250．4±39．2 ms分别降为115．9±25．4 v／s,89．7±11．2 mv,107．7±14．8 ms,164．9±26．7 ms,234．4±39．4 ms,心律泰对RP无影响。结论:心律泰抗心律失常的可能机制与抑制Na ,Ca2 内流、促进K 外流有关。
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| 关 键 词： | 心律泰 心律失常 动作电位 |
| 文章编号： | 1008-049X(2006)06-0488-03 |
| 收稿时间： | 2005-09-27 |
| 修稿时间： | 2006-03-01 |
Effects of Xinlvtai on Action Potential of Ventricular Papillary Muscles in Isolated Guinea Pig |
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| Huang Pu,Wang Guobin,LiuLiqiang,Xu Bailu. Effects of Xinlvtai on Action Potential of Ventricular Papillary Muscles in Isolated Guinea Pig[J]. China Pharmacist, 2006, 9(6): 488-490 |
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| Authors: | Huang Pu Wang Guobin LiuLiqiang Xu Bailu |
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| Abstract: | Objective: To investigate the effects of Xinlvtai on action potential of ventricular papillary muscles in isolated guinea pig. Method: Standard microelectrode intracellular recording technique was used. Result: Xinlvtai decreased APA and slope of Vmax, shortened 20% APD(APD20) ,50% APD(APD50) and 90% APD(APD90) in concentration-dependent manner. It had no significant effect on RP of AP. Conclusion: It was supposed that its mechanism of action was associated with blocking sodium ion and calcium ion influx, promoting potassium ion outflux. |
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| Keywords: | Xinlvtai Arrhythmia Action potential |
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