中药复方对2型糖尿病血管病变患者hs-CRP，IL-6的影响

目的:通过具有益气养阴、活血法的中药复方治疗糖尿病血管病变(DA)患者的临床研究,观察DA患者对超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)的影响。方法:将74名2型DA患者随机分为中药治疗组和空白对照组,两组患者均给予糖尿病基础治疗,治疗组在基础治疗的同时加用益气养阴、活血立法组成的中药复方,疗程8周;对照组只采用糖尿病基础治疗、观察治疗前后患者hs-CRP,IL-6等指标的变化,并对综合疗效进行评价。结果:中药治疗组较对照组患者血清hsCRP,IL-6水平下降明显(P<0.05)。治疗组与对照组相比,患者症状、体征、血糖、血脂、糖化血红蛋白等也有较明显的改善。结论:益气养阴、活血法的中药复方一定程度上降低DA患者hs-CRP,IL-6,有效改善血管炎症状态,胰岛素抵抗及糖脂代谢,对糖尿病血管病变的发生、发展起到有效的防治作用。

Effect of Traditional Chinese Medicine Compound on Hs-CRP and IL-6 of Patients with Vascular Lesions in Type 2 Diabetes

Objective: To observe the effect of traditional Chinese medicine(TCM) compound on high-sensitivity C-reactive protein,interleukin-6 in patients with diabetic angioplasties. Method: Seventy-four patients with diabetic angioplasties(DA) were randomly divided into treatment group and control group. All patients were treated with basic treatment of diabetes. Treatment group was treated with, basic treatment plus TCM decoction ginseng-astragalus compound for 8 weeks;control group was treated with the basic treatment of diabetes.The patients' symptoms, signs, C-reactive protein,interleukin-6 before and after treatment were observed. And comprehensive efficacies were evaluated. Result: Treatment group could significantly reduce the levels of C-reactive protein,interleukin-6.The difference of two groups was statistically significant (P<0.05).Treatment group significantly improved symptoms, signs, blood glucose, blood lipid and glycated hemoglobin of the patients. Conclusion: The method of boosting qi and nourishing yin, transforming stasis and freeing the collaterals can significantly improve the clinical symptoms, reduce C-reactive protein, interleukin-6, effectively improve the status and glucolipid metabolism, and can prevent the occurrence and development of DA.