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M. R. McGinnis G. Campbell W. K. Gourley H. L. Lucia 《European journal of epidemiology》1992,8(3):383-386
A case of phaeohyphomycosis caused by Bipolaris spicifera involving the brain and sinuses is presented. The patient survived following surgery and ketoconazole therapy, which successfully treated both the sinus and the brain infections. 相似文献
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T. Deuel M. Lechpammer A.A. Zamani D.A. Milner R. Folkerth F.M. Marty S. Kesari 《Transplant infectious disease》2011,13(4):419-423
L. Rosow, J.X. Jiang, T. Deuel, M. Lechpammer, A.A. Zamani, D.A. Milner, R. Folkerth, F.M. Marty, S. Kesari. Cerebral phaeohyphomycosis caused by Bipolaris spicifera after heart transplantation.Transpl Infect Dis 2011: 13: 419–423. All rights reserved Abstract: Phaeohyphomycosis is an increasingly recognized cause of brain abscess in both immunocompetent and immunocompromised hosts. We report a case of cerebral phaeohyphomycosis in a 55‐year‐old male heart transplant recipient caused by Bipolaris spicifera. We review the literature regarding the pathogenesis, epidemiology, diagnosis, and management of infections with dematiaceous fungi. 相似文献
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F. R. Lake J. H. Froudist R. McAleer R. L. Gillon A. E. Tribe P. J. Thompson 《Internal medicine journal》1991,21(6):871-874
Abstract Allergic bronchopulmonary fungal disease (ABPFD) usually manifests in asthmatics as allergic bronchopulmonary aspergillosis. In a few instances other fungi have been implicated. Serological testing in Western Australia between 1979 and 1986 revealed precipitins to Bipolaris and Curvularia species in 40 of 503 patients tested. Eight of these were patients with ABPFD due to Bipolaris and/or Curvularia and are reported here. Geographical location appeared to be significant as seven of eight of those with ABPFD (and at least 18 of 40 with positive serology) were living in the more remote and sub-tropical northern part of the state. ABPFD due to fungi other than Aspergillus species may be more common than previously recognised and further epidemiological assessment is warranted. (Aust NZ J Med 1991; 21: 871–874.) 相似文献
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Multiplex polymerase chain reaction (PCR) is a method for simultaneous identification and detection of multiple pathogenic fungi, however, its complexity limits its application. To simplify the protocol and to improve the effectiveness, three‐level designs for six factors (three primers, Taq DNA polymerase, dNTP, Mg2+) were constructed to optimize the multiplex PCR system by using the orthogonal design method and the annealing temperature of the PCR reactions was also optimized. Finally, a multiplex PCR system for the simultaneous detection of these three pathogens of maize was successfully established. The reaction volume was 25 μl and the annealing temperature was 57℃. The optimal conditions for multiplex PCR reaction contained 0.48 μmol/L Cl‐1/Cl‐2, 0.72 μmol/L Bm‐1/Bm‐2, 0.24 μmol/L Az‐1/Az‐2, 1.5 U polymerase, 0.35 mmol/L dNTP, and 1.25 mmol/L MgCl2. The multiplex PCR system can detect Curvularia lunata, Bipolaris maydis, and Aureobasidium zeae in infected plant tissues rapidly with the sensitivity at 10 pg DNA/μl. 相似文献
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Christina A. Mikosz Rachel M. Smith Moon Kim Clara Tyson Ellen H. Lee Eleanor Adams Susanne Straif-Bourgeois Rick Sowadsky Shannon Arroyo Yoran Grant-Greene Julie Duran Yvonne Vasquez Byron F. Robinson Julie R. Harris Shawn R. Lockhart Thomas J. T?r?k Laurene Mascola Benjamin J. Park for the Fungal Endophthalmitis Outbreak Response Team 《Emerging infectious diseases》2014,20(2):248-256
Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck’s Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products. 相似文献
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A. Fryen P. Mayser H. Glanz R. Füssle H. Breithaupt G. S. de Hoog 《European archives of oto-rhino-laryngology》1999,256(7):330-334
Depending on the aggressiveness of the pathogen and a patient’s immunocompetence, fungal polypoid pansinusitis or allergic
fungal sinusitis (AFS) may be a life-threatening disease. Apart from the clinical findings, its diagnosis is based on the
demonstration of mucinous material with abundant eosinophils in the paranasal sinuses (indicating an allergic process), cultivation
of the causative pathogen and immunocompetence of the patient. In a 20-year-old immigrant Sudanese woman, AFS due to Bipolaris (Drechslera) hawaiiensis was diagnosed. Because of intracranial extension, the disease had led to erosion of the cranial base and orbit with amaurosis
on the right side and focal epilepsy. In addition to endonasal microsurgical pansinus operations, local irrigation therapy
with amphothericin B was accompanied by systemic treatment with itraconazole after in vitro cultivation of the pathogen and
determination of its sensitivities. Interdisciplinary management included a combination of endonasal surgery with debridement
of infected tissues and wide drainage of the sinuses without removal of skull bone or the dural lesion in addition to specific
antimycotic treatment. Injury to adjacent anatomical structures must be avoided in any case to prevent systemic or possibly
lethal dissemination of infection.
Received: 27 July 1998 / Accepted: 14 January 1999 相似文献
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Ottó Bencsik Tamás Papp Máté Berta Annamária Zana Péter Forgó Gy?rgy Dombi Maria A. Andersson Mirja Salkinoja-Salonen Csaba Vágv?lgyi András Szekeres 《Toxins》2014,6(9):2857-2871
Bipolaris oryzae is a phytopathogenic fungus causing a brown spot disease in rice, and produces substance that strongly perturbs motility and membrane integrities of boar spermatozoa. The substance was isolated from the liquid culture of the fungal strain using extraction and a multi-step semi-preparative HPLC procedures. Based on the results of mass spectrometric and 2D NMR techniques, the bioactive molecule was identified as ophiobolin A, a previously described sesterterpene-type compound. The purified ophiobolin A exhibited strong motility inhibition and viability reduction on boar spermatozoa. Furthermore, it damaged the sperm mitochondria significantly at sublethal concentration by the dissipation of transmembrane potential in the mitochondrial inner membrane, while the plasma membrane permeability barrier remained intact. The study demonstrated that the cytotoxicity of ophiobolin A toward somatic cell lines is higher by 1–2 orders of magnitude compared to other mitochondriotoxic mycotoxins, and towards sperm cells unique by replacing the progressive motility by shivering tail beating at low exposure concentration. 相似文献
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