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1.
[目的]研究超敏C反应蛋白(hs-CRP)、总抗氧化状态(TAS)联合血脂检测在早老性痴呆症诊断中的应用价值:[方法]选择浦东新区精神卫生中心早老性痴呆专科门诊患者54例,作超敏C反应蛋白、总抗氧化状态与血脂检测。[结果]与对照组比较,实验组hs-CRP、TAS差异非常显著,t1=4.55,t2=2.79,P1〈0.001,P2〈0.01;血脂中甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、Lp(a)差异显著;t1=3.01,P1〈0.01,t2=2.21,P2〈0.05,t3=2.64,P3〈0.01,t4=1.91,P4〈0.05。[结论]超敏C反应蛋白、总抗氧化状态联合血脂(甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B、Lp(a))检测对实验室诊断早老性痴呆症具有较好敏感性和特异性,临床应用前景乐观。 相似文献
2.
Abstract – The type of liquid medium used to store avulsed teeth prior to replantation has been shown to affect the long‐term prognosis. One possibility is that some storage media contain hydrogen peroxide (H2O2) that may be toxic to periodontal ligament cells. Therefore, the aim of this study was to determine if the addition of catalase to storage media improved the prognosis of replanted dog teeth. Forty‐eight mongrel premolar roots were endodontically treated, extracted, randomly divided and placed into one of four storage media: Hank's balanced salt solution (HBSS), containing no antioxidant); Viaspan, containing the antioxidant, glutathione, or the same two media supplemented with catalase(100 U ml?1) for 1, 5, or 26 h prior to replantation. After 2 months, the dogs were euthanized and the roots histologically examined to evaluate the attachment tissues. Regardless of the storage medium used, overall healing was excellent and only 4% of the roots displayed inflammatory or replacement resorption. When roots from the different storage media were compared, those stored in HBSS were found to display the highest incidence of surface resorption (55.7%). Supplementation of HBSS with catalase resulted in a lower level of surface resorption (48.6%) that was statistically significant (P < 0.05). Roots stored in Viaspan – or + catalase displayed even lower levels of surface resorption (41.3 and 38.2%, respectively). The improvement observed with catalase‐supplemented HBSS was confined to the 45‐min incubation period; only Viaspan – or + catalase reduced surface resorption at the 5‐ and 26‐h incubations. Collectively, these data demonstrate that roots stored in media containing antioxidant activity undergo less surface resorption. These results suggest that low levels of H2O2 in storage media for avulsed teeth may adversely affect periodontal ligament cells. 相似文献
3.
4.
In the present study, chlorogenic acid (CGA) isolated from Anthocephalus cadamba was screened for hepatoprotective activity by in vitro and in vivo assay methods using carbon tetrachloride (CCl4) as a model of liver injury. Intraperitoneal administration of CGA to mice at a dose of 100 mg/kg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CCl4-intoxicated mice, revealing that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl4-administered mice. 相似文献
5.
G. I. Bisharova L. I. Kolesnikova V. V. Malyshev 《Bulletin of experimental biology and medicine》1998,126(3):947-949
A comparative study of the parameters of free-radical lipid peroxidation and antioxidant system was performed in children
living in the North for various time periods. Intense lipid peroxidation was shown to be the key factor in the pathogeneses
of several diseases caused by disturbances in the cellular membrane. Decreased resistance of red blood cells to peroxidative
hemolysis is a phenomenon characterizing the adaptation-violating processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 342–344, September, 1998 相似文献
6.
林劲秋 《南方医科大学学报》2002,22(6):530-532
目的探讨外源性补充抗氧化性维生素对骨髓移植病人抗氧化力及脂质过氧化的影响。方法将19名骨髓移植病人随机分为实验和对照组,实验组在预处理前给予维生素C(300 mg/d)和维生素E(600 mg/d),对照组不予补充,其余处理两者相同。测定移植前后两组病人的血浆总抗氧化力、丙二醛、全血谷胱甘肽过氧化物酶及红细胞超氧化物歧化酶水平。结果(1)移植前后实验组血浆总抗氧化力、谷胱甘肽过氧化物酶和红细胞超氧化物歧化酶值一直处于正常或正常值附近,对照组则低于正常值,两组相比有显著差异;(2)移植后实验组丙二醛值很快降至正常,对照组则一直处于较高水平,两组有显著差异。结论移植前外源性补充抗氧化性维生素可提高骨髓移植病人机体的抗氧化力,减少了脂质过氧化物的产生,有效缓解移植前大剂量放、化疗对病人机体造成的高氧化胁迫压力。 相似文献
7.
8.
The heat shock/oxidative stress connection 总被引:2,自引:0,他引:2
M. A. Pappolla M. Sos R. A. Omar K. Sambamurti 《Journal of molecular neuroscience : MN》1996,28(1-3):21-34
Involvement of free-radical oxidations in the aging process has been a topic of interest since Harman's original contribution.
Because of the close association between aging and Alzheimer disease (AD) and the qualitative similarity in the neuropathology
of both conditions, it has been proposed by many investigators that oxidative stress may be important in AD. If such modality
of injury was indeed involved, one should expect to find markers of oxidation and heat shock (since free radicals are key
mediators of heat-shock induction) in brains of patients with AD. In fact, several studies documented abnormal expression
of antioxidant enzymes and heat-shock proteins (HSP) along with other markers of oxidation in AD brains. We showed that abnormally
expressed antioxidant enzymes are topographically associated with senile plaques and neurofibrillary tangles, and that the
activity of these enzymes is (contrary to what one would expect) markedly reduced. These findings have recently been confirmed
by other investigators. Despite a large amount of evidence that suggests an association between oxidative stress and the pathogenesis
of AD, it is not yet known whether oxidative stress is a cause or consequence of the disorder. Future research efforts regarding
the oxidative stress hypothesis of AD should include attempts, at generating AD pathology by oxidative means in laboratory
animals, determining the role and integrity of the heat-shock response in AD, as well as that of various antioxidant systems,
growth factors, and hormones with antioxidant and neuroprotective properties. 相似文献
9.
Cristofori P Crivellente F Campagnola M Pasini AF Garbin U Rigoni A Tosetti M Turton J Faustinelli I Cominacini L 《International journal of experimental pathology》2004,85(2):105-114
A study has been carried out in the apolipoprotein (apo) E-deficient mouse to investigate the activity of lacidipine (a calcium antagonist with antioxidant properties) in inhibiting the development of atherosclerotic lesions; of particular interest were changes in the susceptibility of low-density lipoproteins (LDL) to oxidation. Mice receiving a Western-type diet to accelerate the development of atherosclerosis were treated orally with vehicle or lacidipine at 3 or 10 mg/kg/day for 8 weeks. Lacidipine treatment (at 3 or 10 mg/kg) had no effect on the plasma lipid profile. However, a significant (P < 0.01) dose-related reduction of 43 and 50% of the aortic lesion area in respect to vehicle-treated mice was observed. Moreover, the resistance of mouse plasma LDL to undergo lipid peroxidation was significantly (P < 0.01) increased in apo E-deficient mice treated with lacidipine. The native LDL-like particle, derived from apo E-deficient mice treated with lacidipine, contained significantly lower concentrations of malonyldialdehyde than the vehicle-treated control group (P < 0.01). After exposure to human umbilical vein endothelial cells, LDL-like particle vitamin E levels (expressed as area under the curve; AUC), were significantly higher (P < 0.01) in both the 3 and 10 mg/kg lacidipine-treated groups, in comparison with the vehicle-treated control animals. We conclude that lacidipine reduced the extent of the atherosclerotic area in hypercholesterolaemic apo E-deficient mice, and that this reduction may be associated with the capacity of the drug to decrease the susceptibility of LDL to oxidation. 相似文献
10.
Antioxidant activities of seven histamine receptor blockers are compared using a model system of multilayer liposomes, chemiluminescence
analysis, and 2-thiobarbituric acidreactive substance assay. According to a decrease in the antioxidant activity, the drugs
can be arranged as follows: diprazine, suprastin, tavegil, diazoline, dimedrol, phencarol, and ranitidine. The possible mechanisms
of the antioxidant activity and the significance of the antioxidant properties of these drugs for experimental research and
clinical practice are discussed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No. 12, pp. 638–641, December, 1996 相似文献