全文获取类型
收费全文 | 82745篇 |
免费 | 6056篇 |
国内免费 | 2607篇 |
学科分类
医药卫生 | 91408篇 |
出版年
2024年 | 242篇 |
2023年 | 1149篇 |
2022年 | 2040篇 |
2021年 | 3159篇 |
2020年 | 2875篇 |
2019年 | 2381篇 |
2018年 | 2283篇 |
2017年 | 2587篇 |
2016年 | 2688篇 |
2015年 | 2686篇 |
2014年 | 4872篇 |
2013年 | 5546篇 |
2012年 | 4436篇 |
2011年 | 4801篇 |
2010年 | 3783篇 |
2009年 | 3430篇 |
2008年 | 3580篇 |
2007年 | 3714篇 |
2006年 | 3395篇 |
2005年 | 3117篇 |
2004年 | 2826篇 |
2003年 | 2593篇 |
2002年 | 2248篇 |
2001年 | 2226篇 |
2000年 | 1825篇 |
1999年 | 1554篇 |
1998年 | 1442篇 |
1997年 | 1505篇 |
1996年 | 1279篇 |
1995年 | 1241篇 |
1994年 | 1169篇 |
1993年 | 923篇 |
1992年 | 889篇 |
1991年 | 779篇 |
1990年 | 615篇 |
1989年 | 597篇 |
1988年 | 548篇 |
1987年 | 457篇 |
1986年 | 413篇 |
1985年 | 614篇 |
1984年 | 500篇 |
1983年 | 309篇 |
1982年 | 448篇 |
1981年 | 329篇 |
1980年 | 286篇 |
1979年 | 212篇 |
1978年 | 178篇 |
1977年 | 163篇 |
1976年 | 158篇 |
1975年 | 73篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Aaron Pitzele Mohammad Rahimi Eric Armbrecht 《The journal of maternal-fetal & neonatal medicine》2015,28(15):1770-1773
Objective: To determine whether packed red blood cell (PRBC) transfusion affects post-prandial superior mesenteric artery blood flow velocities (SMA BFVs) in very-low birth weight (VLBW) neonates and if so, at what time point after transfusion restoration of previous SMA BFV patterns occurs.Design/Methods: VLBW pre-term neonates, older than 14 days and tolerating bolus enteral feedings administered every 3?h were enrolled in this prospective observational study. Pulsed Doppler ultrasound was used to measure pre- and post-prandial (at 45?min) time-averaged mean, peak and end diastolic velocities (TAMV, PSV, EDV) immediately before and after 15?ml/kg of PRBC transfusion was given over 3?h; patent ductus arteriosus (PDA) status was also evaluated. Subsequent pre- and post-prandial SMA BFVs were recorded 24 and 48?h after the transfusion.Results: Pre- and post-prandial measurements were obtained for 21 out of 25 enrolled infants. Post-prandial SMA BFVs were attenuated during the feedings immediately after transfusion; at 24 and 48?h after transfusion, changes in post-prandial SMA BFVs were similar to those measured prior to transfusion; the presence of the PDA did not affect results.Conclusions: PRBC transfusion blunted SMA BFV responses to feedings immediately after the transfusion with normalization observed 24?h post-transfusion. 相似文献
2.
《Cor et vasa》2015,57(3):e157-e162
IntroductionObstructive sleep apnea (OSA) is often connected with arterial hypertension and it could also be a cause of secondary hypertension. Treatment of arterial hypertension and optimal blood pressure level are important for prevention of cardiovascular complications. It is not well known how to treat patients with OSA and arterial hypertension. Also many patients with OSA suffer from metabolic syndrome which worsen their prognosis.AimThe aim of our study was to assess arterial hypertension compensation in patients with metabolic syndrome and moderate to severe OSA and to analyze used pharmacotherapy.Materials and methods85 hypertensive patients (75 men) with metabolic syndrome, average age 53.6 ± 9.3 years, were evaluated using overnight sleep study with diagnosis of OSA, average apnea–hypopnea index (AHI) 56.3 ± 23. Patients underwent 24 h ambulatory blood pressure monitoring (ABPM) and their current pharmacotherapy data were obtained. Appropriate combinations of antihypertensive drugs (patients with metabolic syndrome) were derived from ESH/ESC 2013 guidelines.ResultsArterial hypertension was well compensated in only 11.8% of the patients. 24.7% patients were treated according to current guidelines. Fisher's exact test with analysis of adjusted residues has found higher rate of blood pressure subcompensation in patients treated with triple+ combination of drugs (p = 0.035, 51.4% vs 10%).ConclusionOnly a small number of patients had optimal blood pressure level and were treated according to current ESH/ESC guidelines. We have to constantly appeal to all physicians to perform ABPM in patients with OSA. 相似文献
3.
Parallel enzyme‐linked immunosorbent assay screening for human immunodeficiency virus among blood donors in five Chinese blood centres: a retrospective analysis 下载免费PDF全文
4.
《Journal of pharmaceutical sciences》2019,108(7):2500-2504
Accurately predicting the hepatic clearance of compounds using in vitro to in vivo extrapolation (IVIVE) is crucial within the pharmaceutical industry. However, several groups have recently highlighted the serious error in the process. Although empirical or regression-based scaling factors may be used to mitigate the common underprediction, they provide unsatisfying solutions because the reasoning behind the underlying error has yet to be determined. One previously noted trend was intrinsic clearance-dependent underprediction, highlighting the limitations of current in vitro systems. When applying these generated in vitro intrinsic clearance values during drug development and making first-in-human dose predictions for new chemical entities though, hepatic clearance is the parameter that must be estimated using a model of hepatic disposition, such as the well-stirred model. Here, we examine error across hepatic clearance ranges and find a similar hepatic clearance-dependent trend, with high clearance compounds not predicted to be so, demonstrating another gap in the field. 相似文献
5.
6.
7.
Anthony Z Faranesh Dara L Kraitchman Elliot R McVeigh 《Magnetic resonance in medicine》2006,55(5):1114-1123
The purpose of this work was to investigate the use of an intravascular contrast agent to determine perfusion kinetics in skeletal muscle. A two-compartment kinetic model was used to represent the flux of contrast agent between the intravascular space and extravascular extracellular space (EES). The relationship between the image signal-to-noise ratio (SNR) and errors in estimating permeability surface area product (Ktrans), interstitial volume (ve), and plasma volume (vp) for linear and nonlinear curve-fitting methods was estimated from Monte Carlo simulations. Similar results were obtained for both methods. For an image SNR of 60, the estimated errors in these parameters were 10%, 22%, and 17%, respectively. In vivo experiments were conducted in rabbits to examine physiological differences between these parameters in the soleus (SOL) and tibialis anterior (TA) muscles in the hind limb. Values for Ktrans were significantly higher in the SOL (3.2+/-0.9 vs. 2.0+/-0.5x10(-3) min-1), as were values for vp (3.4+/-0.8 vs. 2.1+/-0.7%). Differences in ve for the two muscles (8.7+/-2.2 vs. 8.5+/-1.6%) were not found to be significant. These results demonstrate that relevant physiological metrics can be calculated in skeletal muscle using MRI with an intravascular contrast agent. 相似文献
8.
慢性肺心病哮喘持续状态218例临床分析 总被引:1,自引:0,他引:1
目的探索治疗慢性肺心病哮喘持续状态的方法。方法回顾性分析1983年10月~2005年3月收治的218例慢性肺心病哮喘持续状态患者的临床资料。结果哮喘持续状态在48h以内被控制的62例(28.4%);在72h以内控制的56例(25.7%);在120h以内控制的25例(11.5%);在168h以内控制的34例(15.6%);痊愈出院177例(81.2%);死亡41例(18.8%)。结论(1)治疗慢性肺心病哮喘持续状态.根据患者的病理变化.综合治疗.效果显著。(2)在治疗过程中.要恰当选择抗生素和平喘药;对那些血液黏滞度增高的患者.要加用血液稀释疗法。(3)测定血液黏滞度和氧饱和度.可以指导治疗、估计预后.应当列为常规检查。 相似文献
9.
TOMONORI KATO HIROYOSHI SUZUKI AKIRA KOMIYA TAKASHI IMAMOTO YUKIO NAYA TOYOFUSA TOBE TOMOHIKO ICHIKAWA 《International journal of urology》2006,13(7):915-919
AIM: The clinical significance of the urinary white blood cell (U-WBC) count and serum C-reactive protein (CRP) level was evaluated in an effort to improve the efficiency of prostate biopsies. METHODS: We enrolled 228 consecutive patients with serum prostate-specific antigen (PSA) ranging from 3.0 to 20.0 ng/mL, normal digital rectal examination findings, and who underwent prostate biopsies between January 2001 and August 2004. Of these, 157 patients had histologically confirmed benign prostatic disease and the remaining 71 patients had prostate cancer. Patients with a pretreatment U-WBC count < or =3 or >3/high power field were defined as non-pyuria and pyuria, respectively. The patients were also separated into two groups based on the serum CRP level prior to biopsy. Several clinical factors were compared among these subgroups. RESULTS: Inflammation was histologically detected at rates of 58.1% and 34.1% in the pyuria and non-pyuria groups, respectively (P = 0.0014). The rates of cancer detection were significantly lower in the pyuria, than in the non-pyuria group (P = 0.0384). The cancer detection rates did not significantly differ according to serum CRP levels prior to biopsy. CONCLUSION: The U-WBC count appears to be a reliable indicator of minute prostatic inflammation. The serum PSA level was elevated in patients with asymptomatic prostatitis. Counting U-WBC is a simple, convenient and non-invasive method that should be valuable part of routine urological examinations. 相似文献
10.
目的探讨剖宫产术后深静脉血栓的护理经验。方法将2003年1月~2005年12月行剖宫产术的产妇76例,采取护理干预,加强饮食指导、抗凝血及溶栓护理。结果70例患者治愈,4例留有后遗症,2例转院,未跟踪报告。结论剖宫产术后易发生深静脉血栓;而高龄、经产、多胎、有产科并发症是其高危因素;应用护理措施进行积极干预,起到较好的预防作用,能保证产妇生命安全,提高产科护理质量。 相似文献