全文获取类型
收费全文 | 4044篇 |
免费 | 195篇 |
国内免费 | 47篇 |
学科分类
医药卫生 | 4286篇 |
出版年
2024年 | 83篇 |
2023年 | 136篇 |
2022年 | 160篇 |
2021年 | 206篇 |
2020年 | 202篇 |
2019年 | 323篇 |
2018年 | 299篇 |
2017年 | 252篇 |
2016年 | 251篇 |
2015年 | 168篇 |
2014年 | 295篇 |
2013年 | 210篇 |
2012年 | 240篇 |
2011年 | 236篇 |
2010年 | 227篇 |
2009年 | 154篇 |
2008年 | 169篇 |
2007年 | 122篇 |
2006年 | 127篇 |
2005年 | 86篇 |
2004年 | 85篇 |
2003年 | 62篇 |
2002年 | 33篇 |
2001年 | 43篇 |
2000年 | 18篇 |
1999年 | 13篇 |
1998年 | 8篇 |
1997年 | 8篇 |
1996年 | 10篇 |
1995年 | 13篇 |
1994年 | 6篇 |
1993年 | 9篇 |
1992年 | 11篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1984年 | 2篇 |
1982年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有4286条查询结果,搜索用时 15 毫秒
1.
目的:探究金水宝片联合依诺肝素对维持性血液透析患者血脂代谢的影响。方法:选取2018年12月至2019年3月马鞍山十七冶医院血液净化中心进行透析的患者154例作为研究对象,根据用药不同分为对照组和观察组,每组77例。对照组常规应用依诺肝素抗凝,观察组在对照组抗凝基础上加用金水宝片,各组均干预3个月,比较2组患者血脂变化及持续血液透析并发症发生情况。结果:治疗后,观察组患者三酰甘油、总胆固醇及低密度脂蛋白胆固醇水平下降,高密度脂蛋白胆固醇升高,与治疗前比较差异均有统计学意义(P<0.05),与对照组治疗后比较,差异有统计学意义(P<0.05);观察组总并发症发生率明显低于对照组,2组比较差异有统计学意义(P<0.05);2组患者维持性血液透析不良反应发生率均较低,组间比较差异无统计学意义(P>0.05)。结论:金水宝片联合依诺肝素有助于改善维持性血液透析患者血脂代谢水平,降低维持性血液透析相关并发症,值得临床推广应用。 相似文献
2.
庆余肾气丸,复方丹参片中农药多残留分析 总被引:6,自引:1,他引:5
采用气相色谱法测定庆余肾气丸、复方丹参片中六六六,DDT残留含量,以六六六,DDT各异构体和代谢物衡量,方法的检测极限可达1.8×10-4~8.0×10-3μg/g;方法回收率总均值分别在91.43%±1.7%,和90.88%±2.84%;检测变异系数为0.27%~9.93%。样品测定结果显示,庆余肾气丸、复方丹参片中有机氯农药残留量皆低于世界各国的限量标准。 相似文献
3.
扑苯黄片中三组分的HPLC测定 总被引:1,自引:0,他引:1
用HPLC同时测定扑苯黄片中三组分的含量。采用Spherisorb CN柱,操作简单,结果准确。对乙酰氨基酚、盐酸伪麻黄碱、盐酸苯海拉明的回收率分别为100.3%、99.8%、99.5%,RSD分别为0.29%、0.51%、0.45%。 相似文献
4.
In this paper it is demonstrated how the optimum composition of a mixture for direct compression consisting of -lactose monohydrate, roller-dried -lactose and microcrystalline cellulose can be found using a systematic optimization technique. The experiments were chosen according to a simplex lattice design. The results of these experiments were used to fit a mathematical model, which then can predict the properties of all possible mixture compositions and enables a graphic representation of these properties in the form of contour plots. At a level of 4% the effect of three disintegrants (sodium starch glycolate, croscarmellose sodium and crospovidone) on the properties of the tablets compressed from these filler-binders, was evaluated by superimposing the contour plots of the different tablet responses. It was found that all the disintegrants used were effective in this combination of filler-binders. In order to evaluate drug dissolution rate an extra experiment with crospovidone as the disintegrant was performed, in which oxazepam was used as a test drug. 相似文献
5.
目的 :制备 5_氨基水杨酸缓释骨架片。方法 :采用羟丙基甲基纤维素作为骨架材料 ,湿法制粒压片制备 ,并考察体外释药情况。结果 :5_氨基水杨酸缓释骨架片体外释药符合Higuchi方程。结论 :5_氨基水杨酸缓释骨架片具有显著的缓释效果。 相似文献
6.
The dissolution behaviour of a direct compression compact prepared with sodium diclofenac and dibasic calcium phosphate (DCP) in different weight ratios with or without Biosoluble polymer® (acrylic-based resin) was investigated in distilled water and in a medium with changing pH. The results indicate that the amount of sodium diclofenac released from the compact was dependent on the amount of drug and DCP used in the compact, and was also controlled by the amount of Biosoluble polymer® added. A chemical reaction forming diclofenac acid might occur on the surface of the sodium diclofenac compact during exposure to the acidic medium, which was confirmed by diffuse-reflectance spectroscopy. The tablet with a 12 weight ratio of sodium diclofenac to DCP exhibited a sustained-release behaviour, similar to commercial sustained-release products (Voltaren SR-100® and Grofenac Retard®), but a lower release rate was found as compared to the commercial products. The dissolution behaviour of the study tablet and the commercial products was found to be dependent on the dissolution medium and the rotating speeds. Glass beads were added to the dissolution assembly to simulate the influence of food, and the enhanced friction between tablet and glass beads might result in a higher dissolution rate of the tablet and the commercial products. 相似文献
7.
Twenty-four male volunteers were given obidoxime tablets in quantities ranging from 1.84–3.58 g in a single dose, or 7.36 g divided into 4 equal doses. With the lowest dose, average peak plasma level of the drug was 1.9 g/ml and after the highest single dose it was 5.6 g/ml, both attained 1.5 h after administration. In the multiple-dosed individuals, plasma levels of the oxime increased gradually following each additional dose, reaching a peak of 3.5 g/ml after the last dose.Thirteen individuals complained of one or more of the following side effects: pallor, nausea, pyrosis, headache, generalized weakness, sore throat, and paresthesia of the face muscles.Activities of blood cholinesterase, glutamic oxalacetic transaminase, glutamic pyruvic transaminase, as well as hematocrit values, heart rate, and blood pressure were not affected.It is postulated that due to the undesirable side effects, the general use of obidoxime tablets should not be recommended. However, prophylactic oral treatment with obidoxime could be considered for persons at high risk of organophosphate poisoning or when parenteral administration might not be feasible. 相似文献
8.
目的:考察清火解毒片的药理作用。方法:采用体内外抑菌法、毛细血管通透性法、鼠耳肿胀法、发热反应法、氨雾致咳法、醋酸刺激扭体法。结果:该药对常见的呼吸道感染小鼠有保护作用趋势;对醋酸所致小鼠腹腔毛细血管通透性亢进有明显抑制作用,但对巴豆油所致的小鼠耳肿胀的抑制作用不明显;对2,4-二硝基苯酚致热大鼠的解热作用也不明显;能明显延长氨雾诱发小鼠咳嗽反应潜伏期、减少咳嗽次数;还能明显抑制醋酸所致小鼠的扭体反应。结论:该药具有一定的抗菌、抗炎、镇咳、镇痛作用。 相似文献
9.
藏药晶珠虫草含片质量标准研究 总被引:5,自引:0,他引:5
目的:建立晶珠虫草含片(冬虫夏草,红景天、黄芪、青果、人参、麦冬等)的质量标准。方法:采用TLC法对处方中人参、麦冬进行鉴别;用薄层描法测定黄芪甲苷的含量。结果:在TLC色薄中检出人参、麦冬;黄芪甲苷在0.5-2.5uL范围内呈良好的线性关系,r=0.9999,平均回收率98%。RSD为1.35。结论:所建立的方法简单可行,重现性好,为晶珠虫草含片质量控制提供了方法。 相似文献
10.