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1.
Mingshun Liu Lanjie Gu Po Ma 《现代电生理学杂志》2007,14(1):26-27
目的:探讨脑电地形图在短暂性脑缺血发作诊断中的应用价值.方法:在68例短暂性脑缺血发作患者中,进行了脑电地形图检查.结果:在67(98.52%)例患者中脑电地形图是异常的.40(58.82%)的患者脑电地形图在θ或δ频段显示高功率阴影,在α频段显示低功率阴影.14(20.59%)例患者在α频段显示低功率阴影.12(17.65%)例患者在θ或δ频段显示高功率阴影.1(1.47%)例患者在β频段显示低功率阴影.1(1.47%)例患者正常.结论:脑电地形图在短暂性脑缺血发作的临床诊断中具有重要意义. 相似文献
2.
The Thy-1 antigens or rat brain and thymus have been isolated and chemically characterized, but those of mice have not been identified. Moreover, it is uncertain whether the antigens are glycolipids or glycoproteins. This study with highly purified preparations of gangliosides GM1, 1GD1a, GD1b and GT1b from bovine brain and several ganglioside fractions from mouse brain showed that Thy-1 activity does not reside in gangliosides, but rather in the chloroform-methanol-insoluble residue of brain remaining after extraction of gangliosides. The antigen could be solubilized from this residue with a non-ionic detergent. The antigenic activity of the solubilized preparation was heat-labile but resistant to periodate. The chemical properties of the Thy-1 antigen of mouse brain are discussed. 相似文献
3.
本文报告了急性脑血管病的脑电地形图与脑CT的对比研究。介绍了急性脑血管病的脑电地形图改变,对脑电地形图与脑CT在急性脑血管病诊断上的优劣进行了对比,进一步讨论了脑电地形图在急性脑血管病中的临床应用价值。 相似文献
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Valentina Mazzotta Alessandro Cozzi Lepri Francesca Colavita Silvia Rosati Eleonora Lalle Claudia Cimaglia Jessica Paulicelli Ilaria Mastrorosa Serena Vita Lavinia Fabeni Alessandra Vergori Gaetano Maffongelli Fabrizio Carletti Simone Lanini Emanuela Caraffa Eugenia Milozzi Raffaella Libertone Pierluca Piselli Enrico Girardi AnnaRosa Garbuglia Francesco Vaia Fabrizio Maggi Emanuele Nicastri Andrea Antinori INMI COVID- Outpatient Treatment Study Group 《Journal of medical virology》2023,95(1):e28186
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Irina Kislaya Ausenda Machado Sarah Magalhes Ana Paula Rodrigues Rafael Franco Pedro Pinto Leite Carlos Matias Dias Baltazar Nunes 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(37)
We measured vaccine effectiveness (VE) against COVID-19-related severe outcomes in elderly people in Portugal between May and July 2022. In ≥ 80 year-olds, the second booster dose VE was 81% (95% CI: 75–85) and 82% (95% CI: 77–85), respectively, against COVID-19-related hospitalisation and death. The first booster dose VE was 63% (95% CI: 55–70) in ≥ 80 year-olds and 74% (95% CI: 66–80) in 60–79 year-olds against hospitalisation, and 63% (95% CI: 57–69) and 65% (95% CI: 54–74) against death. 相似文献
8.
Ramadan Abdelmoez Farahat Abdelaziz Abdelaal Tungki Pratama Umar Amro A. El-Sakka Amira Yasmine Benmelouka Khaled Albakri Iftikhar Ali Tareq Al-Ahdal Basel Abdelazeem Ranjit Sah Alfonso J. Rodriguez-Morales 《Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive》2022,30(4):480
9.
目的:研究黄芩苷对糖尿病大鼠的降血糖作用及其对大鼠小肠二糖酶的影响。方法:用大鼠小肠刷状缘膜匀浆分析黄芩苷对二糖酶活性的抑制作用;测定黄芩苷对正常小鼠蔗糖负荷糖耐量的影响;观察腹腔注射65mg.kg^-1链脲佐菌素(Streptozotocin,STZ)诱导的糖尿病大鼠用黄芩苷100和200mg.kg^-1治疗4周后,蔗糖负荷糖耐量,实验结束后,分析十二指肠、空肠和回肠黏膜中蔗糖酶的活力。结果:黄芩苷对蔗糖酶活性有抑制作用,对麦芽糖酶活性无抑制作用:正常小鼠灌胃给予黄芩苷后,显著降低蔗糖引起的血糖水平升高。糖尿病大鼠灌胃给予黄芩苷周后,黄芩苷显著降低糖尿病大鼠的血糖水平,减缓糖尿病大鼠体重降低的趋势,同时黄芩苷显著降低糖尿病导致的蔗糖酶活力增强。结论:黄芩苷降低血糖的机制之一可能是抑制小肠蔗糖酶的活性。 相似文献
10.
Callie Drennen Erin Gorse Robert E. Stratford 《Journal of pharmaceutical sciences》2018,107(4):1194-1203
Pharmacokinetic modeling was used to describe 5 (and 6)-carboxy-2′,7′-dichloroflourescein (CDF) disposition in Caco-2 cells following CDF or CDFDA (CDF diacetate) dosing. CDF transcellular flux was modeled by simple passive diffusion. CDFDA dosing models were based on simultaneous fitting of CDF levels in apical, basolateral, and intracellular compartments. Predicted CDF efflux was 50% higher across the apical versus the basolateral membrane. This difference was similar following apical and basolateral CDFDA dosing, despite intracellular levels being 3-fold higher following basolateral dosing, thus supporting nonsaturable CDF efflux kinetics. A 3-compartment catenary model with intracellular CDFDA hydrolysis described CDF disposition. This model predicted that apical CDF efflux was not altered in the presence of MK-571, and that basolateral membrane clearance was enhanced to account for reduced intracellular CDF in the presence of this multidrug resistance-associated protein (MRP) inhibitor. Similar effects were predicted for glyceollin, while genistein exposure had no predicted effects on CDF efflux. These modulator effects are discussed in the context of model predicted intracellular CDF concentrations relative to reports of CDF affinity (measured by Km) for MRP2 and MRP3. This model-based analysis confirms the complexity of efflux kinetics and suggests that other transporters may have contributed to CDF efflux. 相似文献