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1.
豫谷6号是应用有性杂交技术,经连续南繁、温室加代选择育成的夏谷新品种。具有高产稳产、高抗倒伏、高度抗旱、综合抗病力强等优良特性,适宜中等以上肥力水、旱地种植。 相似文献
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Although the molluscicide Frescon is a strong neurotoxin to the Lymnaea stagnalis central nervous system in vitro, it is probable that the exposure of the whole animal to this molluscicide fails to result in central nervous system abnormalities: Frescon does not appear to reach the brain in sufficient quantity to disrupt its normal activity. However, only those Frescon analogs found to be neurotoxic were molluscicidal, suggesting some related mode, if not site, of action. Frescon and its analogs may act by affecting excitable tissues other than the nervous system (e.g., the snail musculature) by altering certain functional and/or structural membrane properties. 相似文献
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Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism 下载免费PDF全文
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Branched‐chain amino acid ratios in low‐protein diets regulate the free amino acid profile and the expression of hepatic fatty acid metabolism‐related genes in growing pigs 下载免费PDF全文
Y. H. Duan F. N. Li C. Y. Wen W. L. Wang Q. P. Guo Y. H. Li Y. L. Yin 《Journal of animal physiology and animal nutrition》2018,102(1):e43-e51
Liver metabolism is affected by nutrients. The aim of this study was to explore the effects of low‐protein diets (17% crude protein, CP) supplemented with branched‐chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile) and valine (Val), on hepatic amino acid profile and lipid metabolism in growing pigs. The ratio of Leu : Ile : Val in all groups was 1 : 0.51 : 0.63 (20% crude protein, CP), 1 : 1 : 1 (17% CP), 1 : 0.75 : 0.75 (17% CP), 1 : 0.51 : 0.63 (17% CP) and 1 : 0.25 : 0.25 (17% CP) respectively. Results revealed that compared to the positive control group (1 : 0.51 : 0.63, 20% CP), the low‐protein diets significantly augmented the concentrations of most essential amino acids and non‐essential amino acids (p < .05), with the greatest values observed in the 1 : 0.25 : 0.25 group. Moreover, relative to the control, the low‐protein diets with the Leu : Ile : Val ratio ranging from 1 : 0.75 : 0.75 to 1 : 0.25 : 0.25 markedly downregulated the mRNA abundance of acetyl‐CoA carboxylase (ACC), lipoprotein lipase (LPL) and fatty acid‐binding protein 4 (FABP‐4) (p < .05), and upregulated the mRNA expression of hormone‐sensitive lipase (HSL), peroxisome proliferator‐activated receptor‐g coactivator‐1α (PGC‐1α), uncoupling protein 3 (UCP3) and liver carnitine palmitoyltransferase 1 (L‐CPT‐1) (p < .05). Therefore, our data suggest that protein‐restricted diets supplemented with optimal BCAA ratio, that is, 1 : 0.75 : 0.75–1 : 0.25 : 0.25, induce a shift from fatty acid synthesis to fatty acid oxidation in the liver of growing pigs. These effects may be associated with increased mitochondrial biogenesis. 相似文献
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Background: CDK4/6 (Cyclin-dependent kinases 4/6) are the key promoters of cell cycle transition from G1 phase to S phase. Thus, selective inhibition of CDK4/6 is a promising cancer treatment. Methods: A total of 52,765 marine natural products were screened for CDK4/6. To screen out better natural compounds, pharmacophore models were first generated, then the absorption, distribution, metabolism, elimination, and toxicity (ADMET) were tested, followed by molecular docking. Finally, molecular dynamics simulation was carried out to verify the binding characteristics of the selected compounds. Results: Eighty-seven marine small molecules were screened based on the pharmacophore model. Then, compounds 41369 and 50843 were selected according to the ADMET and molecular docking score for further kinetic simulation evaluation. Finally, through molecular dynamics analysis, it was confirmed that compound 50843 maintained a stable conformation with the target protein, so it has the opportunity to become an inhibitor of CDK4/6. Conclusion: Through structure-based pharmacophore modeling, ADMET, the molecular docking method and molecular dynamics (MD) simulation, marine natural compound 50843 was proposed as a promising marine inhibitor of CDK4/6. 相似文献
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Rab是真核生物细胞器进行物质交换和信息传递重要的小分子结合蛋白。研究采用RT-PCR方法从22周龄母鸡脂肪组织中克隆了Rab6基因的cDNA序列。序列长度为774bp,包含1个627bp完整的CDS,编码208个氨基酸。该序列(Genbank No:DQ470138)与鸭、人、小鼠、狗的Rab6有85.8%~93.1%的同源性,而相应蛋白的同源性达97.6%以上。蛋白预测的分子量和等电点分别为23490Da、5.42,与鸭、人、小鼠、狗的Rab6蛋白高度相似,在78~102氨基酸处有1个跨膜结构。分析结果表明Rab6基因及其蛋白质在动物进化中是高度保守的。 相似文献
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湘椒6号是由湖南地方良种伏地尖中选出的自交系F81-1-2从北方引进的甜椒品种经6代单株选择而成L24-1自交系配制而成的一代杂各。该品种植株生长势强,耐寒、耐湿,果实粗牛角形,果色深绿,微辣,商品性好。从定值致收获35 ̄45天,667m^2产鲜椒3000kg。田间表现抗病毒病、疮痂病。 相似文献